Comparative Assessment of Antioxidant, Anti-Diabetic and Cytotoxic Effects of Three Peel/Shell Food Waste Extract-Mediated Silver Nanoparticles

Gitishree Das,1 Han-Seung Shin,2 Jayanta Kumar Patra1 1Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of Korea; 2Department of Food Science and Biotechnology, Dongguk University-Seoul, Gyeonggi‐do, 10326, Republic of Ko...

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Autores principales:	Das G, Shin HS, Patra JK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	antidiabetic antioxidant cytotoxicity food wastes peels/shells silver nanoparticles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3c8edc49e0974f3aa42f493ec3221778
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spelling	oai:doaj.org-article:3c8edc49e0974f3aa42f493ec32217782021-12-02T12:02:21ZComparative Assessment of Antioxidant, Anti-Diabetic and Cytotoxic Effects of Three Peel/Shell Food Waste Extract-Mediated Silver Nanoparticles1178-2013https://doaj.org/article/3c8edc49e0974f3aa42f493ec32217782020-11-01T00:00:00Zhttps://www.dovepress.com/comparative-assessment-of-antioxidant-anti-diabetic-and-cytotoxic-effe-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Gitishree Das,1 Han-Seung Shin,2 Jayanta Kumar Patra1 1Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of Korea; 2Department of Food Science and Biotechnology, Dongguk University-Seoul, Gyeonggi‐do, 10326, Republic of KoreaCorrespondence: Jayanta Kumar PatraResearch Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of KoreaEmail jkpatra@dongguk.eduBackground: The natural food waste peels/shells discarded as waste materials are ample sources of natural bioactive compounds. The natural food waste mediated silver (Ag) nanoparticle (NPs) synthesis will be advantageous over chemical synthesis.Materials and Methods: Using the various phytochemical-rich ripe P. americana peel (PAP), fresh Beta vulgaris peel (BVP), and rawArachis hypogaea shell (AHS) extracts, the bio-synthesis of PAP-AgNPs, BVP-AgNPs, and AHS-AgNPs, respectively, were carried out and its characterization was completed by standard procedures. The three biosynthesized AgNP’s multiple biological effects were accomplished by evaluating their cytotoxicity, antidiabetic, and antioxidant effects.Results: The biosynthesis of the three generated Ag nanoparticles was confirmed through UV-vis spectrum analysis while the X-ray diffraction outlines revealed the generated AgNPs nature. The morphological structure and elemental information of the three AgNPs were obtained through SEM (scanning electron microscopy) and EDX (energy-dispersive X-ray) study. Multiple biological assays exhibited that the three generated AgNPs have significant cytotoxic, antidiabetic, and moderate antioxidant activity. In a comparative analysis, the PAP-AgNPs displayed higher anticancer potential than BVP and AHS-AgNPs, whereas AHS-AgNPs exhibited a higher antidiabetic effect with the lowest IC50 value (1.68 μg/mL) than PAP and BVP AgNPs. All three generated AgNPs displayed moderate antioxidant effects, among them BVP-AgNPs were more effective than PAP and AHS AgNPs. More than two effects of the three biosynthesized AgNPs specifies that they have ample perspective in therapeutic applications in pharmaceutical and other related industries in controlling cancer and diabetes.Keywords: antidiabetic, antioxidant, cytotoxicity, food wastes, peels/shells, silver nanoparticlesDas GShin HSPatra JKDove Medical Pressarticleantidiabeticantioxidantcytotoxicityfood wastespeels/shellssilver nanoparticlesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 9075-9088 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	antidiabetic antioxidant cytotoxicity food wastes peels/shells silver nanoparticles Medicine (General) R5-920
spellingShingle	antidiabetic antioxidant cytotoxicity food wastes peels/shells silver nanoparticles Medicine (General) R5-920 Das G Shin HS Patra JK Comparative Assessment of Antioxidant, Anti-Diabetic and Cytotoxic Effects of Three Peel/Shell Food Waste Extract-Mediated Silver Nanoparticles
description	Gitishree Das,1 Han-Seung Shin,2 Jayanta Kumar Patra1 1Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of Korea; 2Department of Food Science and Biotechnology, Dongguk University-Seoul, Gyeonggi‐do, 10326, Republic of KoreaCorrespondence: Jayanta Kumar PatraResearch Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of KoreaEmail jkpatra@dongguk.eduBackground: The natural food waste peels/shells discarded as waste materials are ample sources of natural bioactive compounds. The natural food waste mediated silver (Ag) nanoparticle (NPs) synthesis will be advantageous over chemical synthesis.Materials and Methods: Using the various phytochemical-rich ripe P. americana peel (PAP), fresh Beta vulgaris peel (BVP), and rawArachis hypogaea shell (AHS) extracts, the bio-synthesis of PAP-AgNPs, BVP-AgNPs, and AHS-AgNPs, respectively, were carried out and its characterization was completed by standard procedures. The three biosynthesized AgNP’s multiple biological effects were accomplished by evaluating their cytotoxicity, antidiabetic, and antioxidant effects.Results: The biosynthesis of the three generated Ag nanoparticles was confirmed through UV-vis spectrum analysis while the X-ray diffraction outlines revealed the generated AgNPs nature. The morphological structure and elemental information of the three AgNPs were obtained through SEM (scanning electron microscopy) and EDX (energy-dispersive X-ray) study. Multiple biological assays exhibited that the three generated AgNPs have significant cytotoxic, antidiabetic, and moderate antioxidant activity. In a comparative analysis, the PAP-AgNPs displayed higher anticancer potential than BVP and AHS-AgNPs, whereas AHS-AgNPs exhibited a higher antidiabetic effect with the lowest IC50 value (1.68 μg/mL) than PAP and BVP AgNPs. All three generated AgNPs displayed moderate antioxidant effects, among them BVP-AgNPs were more effective than PAP and AHS AgNPs. More than two effects of the three biosynthesized AgNPs specifies that they have ample perspective in therapeutic applications in pharmaceutical and other related industries in controlling cancer and diabetes.Keywords: antidiabetic, antioxidant, cytotoxicity, food wastes, peels/shells, silver nanoparticles
format	article
author	Das G Shin HS Patra JK
author_facet	Das G Shin HS Patra JK
author_sort	Das G
title	Comparative Assessment of Antioxidant, Anti-Diabetic and Cytotoxic Effects of Three Peel/Shell Food Waste Extract-Mediated Silver Nanoparticles
title_short	Comparative Assessment of Antioxidant, Anti-Diabetic and Cytotoxic Effects of Three Peel/Shell Food Waste Extract-Mediated Silver Nanoparticles
title_full	Comparative Assessment of Antioxidant, Anti-Diabetic and Cytotoxic Effects of Three Peel/Shell Food Waste Extract-Mediated Silver Nanoparticles
title_fullStr	Comparative Assessment of Antioxidant, Anti-Diabetic and Cytotoxic Effects of Three Peel/Shell Food Waste Extract-Mediated Silver Nanoparticles
title_full_unstemmed	Comparative Assessment of Antioxidant, Anti-Diabetic and Cytotoxic Effects of Three Peel/Shell Food Waste Extract-Mediated Silver Nanoparticles
title_sort	comparative assessment of antioxidant, anti-diabetic and cytotoxic effects of three peel/shell food waste extract-mediated silver nanoparticles
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/3c8edc49e0974f3aa42f493ec3221778
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Comparative Assessment of Antioxidant, Anti-Diabetic and Cytotoxic Effects of Three Peel/Shell Food Waste Extract-Mediated Silver Nanoparticles

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