Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Coronavirus main protease is essential for viral polyprotein processing and replication. Here Vuong et al. report efficient inhibition of SARS-CoV-2 replication by the dipeptide-based protease inhibitor GC376 and its parent GC373, which were originally used to treat feline coronavirus infection.

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Autores principales:	Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c902c5ef40f40398c856f91dffa7d74
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:3c902c5ef40f40398c856f91dffa7d742021-12-02T19:02:33ZFeline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication10.1038/s41467-020-18096-22041-1723https://doaj.org/article/3c902c5ef40f40398c856f91dffa7d742020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18096-2https://doaj.org/toc/2041-1723Coronavirus main protease is essential for viral polyprotein processing and replication. Here Vuong et al. report efficient inhibition of SARS-CoV-2 replication by the dipeptide-based protease inhibitor GC376 and its parent GC373, which were originally used to treat feline coronavirus infection.Wayne VuongMuhammad Bashir KhanConrad FischerElena ArutyunovaTess LamerJustin ShieldsHolly A. SaffranRyan T. McKayMarco J. van BelkumMichael A. JoyceHoward S. YoungD. Lorne TyrrellJohn C. VederasM. Joanne LemieuxNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wayne Vuong Muhammad Bashir Khan Conrad Fischer Elena Arutyunova Tess Lamer Justin Shields Holly A. Saffran Ryan T. McKay Marco J. van Belkum Michael A. Joyce Howard S. Young D. Lorne Tyrrell John C. Vederas M. Joanne Lemieux Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
description	Coronavirus main protease is essential for viral polyprotein processing and replication. Here Vuong et al. report efficient inhibition of SARS-CoV-2 replication by the dipeptide-based protease inhibitor GC376 and its parent GC373, which were originally used to treat feline coronavirus infection.
format	article
author	Wayne Vuong Muhammad Bashir Khan Conrad Fischer Elena Arutyunova Tess Lamer Justin Shields Holly A. Saffran Ryan T. McKay Marco J. van Belkum Michael A. Joyce Howard S. Young D. Lorne Tyrrell John C. Vederas M. Joanne Lemieux
author_facet	Wayne Vuong Muhammad Bashir Khan Conrad Fischer Elena Arutyunova Tess Lamer Justin Shields Holly A. Saffran Ryan T. McKay Marco J. van Belkum Michael A. Joyce Howard S. Young D. Lorne Tyrrell John C. Vederas M. Joanne Lemieux
author_sort	Wayne Vuong
title	Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
title_short	Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
title_full	Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
title_fullStr	Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
title_full_unstemmed	Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
title_sort	feline coronavirus drug inhibits the main protease of sars-cov-2 and blocks virus replication
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3c902c5ef40f40398c856f91dffa7d74
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Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

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