Astragalus Polysaccharides and Saponins Alleviate Liver Injury and Regulate Gut Microbiota in Alcohol Liver Disease Mice

Astragalus, a medical and edible plant in China, shows several bioactive properties. However, the role of astragalus in attenuating alcoholic liver disease (ALD) is less clear. The objective of this project is to investigate the improving effect of astragalus saponins (AS) and astragalus polysacchar...

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Autores principales:	Jingxuan Zhou, Nanhai Zhang, Liang Zhao, Wei Wu, Liebing Zhang, Feng Zhou, Jingming Li
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	astragalus alcoholic liver disease polysaccharides saponins gut microbiota Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/3c90e256c9d449c6bcbb447fb9738e59
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spelling	oai:doaj.org-article:3c90e256c9d449c6bcbb447fb9738e592021-11-25T17:34:14ZAstragalus Polysaccharides and Saponins Alleviate Liver Injury and Regulate Gut Microbiota in Alcohol Liver Disease Mice10.3390/foods101126882304-8158https://doaj.org/article/3c90e256c9d449c6bcbb447fb9738e592021-11-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2688https://doaj.org/toc/2304-8158Astragalus, a medical and edible plant in China, shows several bioactive properties. However, the role of astragalus in attenuating alcoholic liver disease (ALD) is less clear. The objective of this project is to investigate the improving effect of astragalus saponins (AS) and astragalus polysaccharides (AP), which are the two primary constituents in astragalus on hepatic injury induced by alcohol, and the potential mechanisms of action. Different doses of AS (50 and 100 mg/kg bw) and AP (300 and 600 mg/kg bw) were orally given to alcohol-treated mice for four weeks. The results demonstrated that both AP and AS could reverse the increase of the levels of TC, TG, FFA, and LDL-C in serum, and the decrease of serum HDL-C content, as well as the elevation of hepatic TC and TG levels induced by alcohol. The activities of AST, ALT, ALP, and γ-GT in ALD mice were raised after AP and AS supplementation. The antioxidant markers (SOD, CAT, GSH, and GSH-Px) were obviously augmented and the pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) and hepatic histological variations were alleviated by AP and AS, which was in line with the levels of oxidative stress-associated genes (<i>Keap1</i>, <i>Nfe2l2</i>, <i>Nqo1</i>, and <i>Hmox1</i>) and inflammation-associated genes (<i>Tlr4</i>, <i>Myd88</i> and <i>Nfkb1</i>). In addition, AS exerted a more efficient effect than AP and the results presented dose proportionality. Moreover, AS and AP could modulate the intestinal microbiota disturbance induced by alcohol. Overall, AS and AP administration could ameliorate lipid accumulation in the serum and liver, as well as hepatic function, oxidative stress, inflammatory response, and gut flora disorders in mice as a result of alcohol.Jingxuan ZhouNanhai ZhangLiang ZhaoWei WuLiebing ZhangFeng ZhouJingming LiMDPI AGarticleastragalusalcoholic liver diseasepolysaccharidessaponinsgut microbiotaChemical technologyTP1-1185ENFoods, Vol 10, Iss 2688, p 2688 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	astragalus alcoholic liver disease polysaccharides saponins gut microbiota Chemical technology TP1-1185
spellingShingle	astragalus alcoholic liver disease polysaccharides saponins gut microbiota Chemical technology TP1-1185 Jingxuan Zhou Nanhai Zhang Liang Zhao Wei Wu Liebing Zhang Feng Zhou Jingming Li Astragalus Polysaccharides and Saponins Alleviate Liver Injury and Regulate Gut Microbiota in Alcohol Liver Disease Mice
description	Astragalus, a medical and edible plant in China, shows several bioactive properties. However, the role of astragalus in attenuating alcoholic liver disease (ALD) is less clear. The objective of this project is to investigate the improving effect of astragalus saponins (AS) and astragalus polysaccharides (AP), which are the two primary constituents in astragalus on hepatic injury induced by alcohol, and the potential mechanisms of action. Different doses of AS (50 and 100 mg/kg bw) and AP (300 and 600 mg/kg bw) were orally given to alcohol-treated mice for four weeks. The results demonstrated that both AP and AS could reverse the increase of the levels of TC, TG, FFA, and LDL-C in serum, and the decrease of serum HDL-C content, as well as the elevation of hepatic TC and TG levels induced by alcohol. The activities of AST, ALT, ALP, and γ-GT in ALD mice were raised after AP and AS supplementation. The antioxidant markers (SOD, CAT, GSH, and GSH-Px) were obviously augmented and the pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) and hepatic histological variations were alleviated by AP and AS, which was in line with the levels of oxidative stress-associated genes (<i>Keap1</i>, <i>Nfe2l2</i>, <i>Nqo1</i>, and <i>Hmox1</i>) and inflammation-associated genes (<i>Tlr4</i>, <i>Myd88</i> and <i>Nfkb1</i>). In addition, AS exerted a more efficient effect than AP and the results presented dose proportionality. Moreover, AS and AP could modulate the intestinal microbiota disturbance induced by alcohol. Overall, AS and AP administration could ameliorate lipid accumulation in the serum and liver, as well as hepatic function, oxidative stress, inflammatory response, and gut flora disorders in mice as a result of alcohol.
format	article
author	Jingxuan Zhou Nanhai Zhang Liang Zhao Wei Wu Liebing Zhang Feng Zhou Jingming Li
author_facet	Jingxuan Zhou Nanhai Zhang Liang Zhao Wei Wu Liebing Zhang Feng Zhou Jingming Li
author_sort	Jingxuan Zhou
title	Astragalus Polysaccharides and Saponins Alleviate Liver Injury and Regulate Gut Microbiota in Alcohol Liver Disease Mice
title_short	Astragalus Polysaccharides and Saponins Alleviate Liver Injury and Regulate Gut Microbiota in Alcohol Liver Disease Mice
title_full	Astragalus Polysaccharides and Saponins Alleviate Liver Injury and Regulate Gut Microbiota in Alcohol Liver Disease Mice
title_fullStr	Astragalus Polysaccharides and Saponins Alleviate Liver Injury and Regulate Gut Microbiota in Alcohol Liver Disease Mice
title_full_unstemmed	Astragalus Polysaccharides and Saponins Alleviate Liver Injury and Regulate Gut Microbiota in Alcohol Liver Disease Mice
title_sort	astragalus polysaccharides and saponins alleviate liver injury and regulate gut microbiota in alcohol liver disease mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3c90e256c9d449c6bcbb447fb9738e59
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Astragalus Polysaccharides and Saponins Alleviate Liver Injury and Regulate Gut Microbiota in Alcohol Liver Disease Mice

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