Low creatinine levels in diabetes mellitus among older individuals: the Yuport Medical Checkup Center Study

Abstract ORIC ID: 0000-0002-3401-8191. It is unknown whether the interrelationship between diabetes and muscle loss is affected by ageing. Therefore, the serum creatinine levels, an indicator of muscle mass, were compared between older people with diabetes and those without diabetes, using a cross-s...

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Autores principales:	Saori Kashima, Kazuo Inoue, Masatoshi Matsumoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3c91f3c0f8f242e4869ccd5188e47c11
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spelling	oai:doaj.org-article:3c91f3c0f8f242e4869ccd5188e47c112021-12-02T16:31:52ZLow creatinine levels in diabetes mellitus among older individuals: the Yuport Medical Checkup Center Study10.1038/s41598-021-94441-92045-2322https://doaj.org/article/3c91f3c0f8f242e4869ccd5188e47c112021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94441-9https://doaj.org/toc/2045-2322Abstract ORIC ID: 0000-0002-3401-8191. It is unknown whether the interrelationship between diabetes and muscle loss is affected by ageing. Therefore, the serum creatinine levels, an indicator of muscle mass, were compared between older people with diabetes and those without diabetes, using a cross-sectional dataset from the Yuport Medical Checkup Center Study. We classified 6133 participants without kidney dysfunction into three age-groups: early-elderly (65–69 years), middle-elderly (70–74 years), and late-elderly (≥ 75 years). The association between diabetes and the lowest creatinine level, defined as less than or equal to the 25 percentile of serum creatinine, was evaluated in each age group, by calculating the odds ratio (OR) using logistic regression. Serum creatinine levels increased with ageing in the participants, and these trends were markedly observed in the non-diabetic group. Late-elderly people with diabetes were significantly more likely to have low creatinine levels than those without diabetes, with adjusted ORs 2.50 (95% CI 1.99–4.50) in men and 2.88 (95% CI 1.47–5.64) in women. Ageing modified the effect of their diabetes status towards a lower creatinine level (p for interactions between the diabetic status and age-groups were 0.01 in men and 0.05 in women, respectively). Ageing may thus accelerate the loss of muscle mass in people with diabetes.Saori KashimaKazuo InoueMasatoshi MatsumotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Saori Kashima Kazuo Inoue Masatoshi Matsumoto Low creatinine levels in diabetes mellitus among older individuals: the Yuport Medical Checkup Center Study
description	Abstract ORIC ID: 0000-0002-3401-8191. It is unknown whether the interrelationship between diabetes and muscle loss is affected by ageing. Therefore, the serum creatinine levels, an indicator of muscle mass, were compared between older people with diabetes and those without diabetes, using a cross-sectional dataset from the Yuport Medical Checkup Center Study. We classified 6133 participants without kidney dysfunction into three age-groups: early-elderly (65–69 years), middle-elderly (70–74 years), and late-elderly (≥ 75 years). The association between diabetes and the lowest creatinine level, defined as less than or equal to the 25 percentile of serum creatinine, was evaluated in each age group, by calculating the odds ratio (OR) using logistic regression. Serum creatinine levels increased with ageing in the participants, and these trends were markedly observed in the non-diabetic group. Late-elderly people with diabetes were significantly more likely to have low creatinine levels than those without diabetes, with adjusted ORs 2.50 (95% CI 1.99–4.50) in men and 2.88 (95% CI 1.47–5.64) in women. Ageing modified the effect of their diabetes status towards a lower creatinine level (p for interactions between the diabetic status and age-groups were 0.01 in men and 0.05 in women, respectively). Ageing may thus accelerate the loss of muscle mass in people with diabetes.
format	article
author	Saori Kashima Kazuo Inoue Masatoshi Matsumoto
author_facet	Saori Kashima Kazuo Inoue Masatoshi Matsumoto
author_sort	Saori Kashima
title	Low creatinine levels in diabetes mellitus among older individuals: the Yuport Medical Checkup Center Study
title_short	Low creatinine levels in diabetes mellitus among older individuals: the Yuport Medical Checkup Center Study
title_full	Low creatinine levels in diabetes mellitus among older individuals: the Yuport Medical Checkup Center Study
title_fullStr	Low creatinine levels in diabetes mellitus among older individuals: the Yuport Medical Checkup Center Study
title_full_unstemmed	Low creatinine levels in diabetes mellitus among older individuals: the Yuport Medical Checkup Center Study
title_sort	low creatinine levels in diabetes mellitus among older individuals: the yuport medical checkup center study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3c91f3c0f8f242e4869ccd5188e47c11
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Low creatinine levels in diabetes mellitus among older individuals: the Yuport Medical Checkup Center Study

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