Antioxidant and Anti-Inflammatory Activity of <i>Cynanchum acutum</i> L. Isolated Flavonoids Using Experimentally Induced Type 2 Diabetes Mellitus: Biological and In Silico Investigation for NF-κB Pathway/miR-146a Expression Modulation

Antioxidant and Anti-Inflammatory Activity of <i>Cynanchum acutum</i> L. Isolated Flavonoids Using Experimentally Induced Type 2 Diabetes Mellitus: Biological and In Silico Investigation for NF-κB Pathway/miR-146a Expression Modulation

<i>Cynanchum acutum</i> L. is a climbing vine that belongs to the family Apocynaceae. Using different chromatographic techniques, seven compounds were isolated from the methanolic extract of the plant. The isolated compounds include six flavonoid compounds identified as rutin (<b>1...

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Bibliographic Details
Main Authors: Reda F. A. Abdelhameed, Amany K. Ibrahim, Mahmoud A. Elfaky, Eman S. Habib, Mayada I. Mahamed, Eman T. Mehanna, Khaled M. Darwish, Dina M. Khodeer, Safwat A. Ahmed, Sameh S. Elhady
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
Apocynaceae
<i>Cynanchumacutum</i>
flavonoids
miR-146a
nuclear factor kappa B
tumor necrosis factor-alpha
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/3c922f885c194902b0c1d97a122d5acd
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