Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation

α-Tertiary amides are common in bioactive natural products and pharmaceuticals, but challenging to access by conventional methods. Here, the authors report a single-step approach toward α-tertiary amides via cobalt-catalyzed intermolecular oxidative hydroamidation of unactivated alkenes.

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Auteurs principaux:	Yun-Nian Yin, Rui-Qi Ding, Dong-Chen Ouyang, Qing Zhang, Rong Zhu
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/3c93a1ac7caf497db46b81975ce37d37
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spelling	oai:doaj.org-article:3c93a1ac7caf497db46b81975ce37d372021-12-02T14:29:13ZHighly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation10.1038/s41467-021-22373-z2041-1723https://doaj.org/article/3c93a1ac7caf497db46b81975ce37d372021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22373-zhttps://doaj.org/toc/2041-1723α-Tertiary amides are common in bioactive natural products and pharmaceuticals, but challenging to access by conventional methods. Here, the authors report a single-step approach toward α-tertiary amides via cobalt-catalyzed intermolecular oxidative hydroamidation of unactivated alkenes.Yun-Nian YinRui-Qi DingDong-Chen OuyangQing ZhangRong ZhuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yun-Nian Yin Rui-Qi Ding Dong-Chen Ouyang Qing Zhang Rong Zhu Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
description	α-Tertiary amides are common in bioactive natural products and pharmaceuticals, but challenging to access by conventional methods. Here, the authors report a single-step approach toward α-tertiary amides via cobalt-catalyzed intermolecular oxidative hydroamidation of unactivated alkenes.
format	article
author	Yun-Nian Yin Rui-Qi Ding Dong-Chen Ouyang Qing Zhang Rong Zhu
author_facet	Yun-Nian Yin Rui-Qi Ding Dong-Chen Ouyang Qing Zhang Rong Zhu
author_sort	Yun-Nian Yin
title	Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
title_short	Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
title_full	Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
title_fullStr	Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
title_full_unstemmed	Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
title_sort	highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3c93a1ac7caf497db46b81975ce37d37
work_keys_str_mv	AT yunnianyin highlychemoselectivesynthesisofhinderedamidesviacobaltcatalyzedintermolecularoxidativehydroamidation AT ruiqiding highlychemoselectivesynthesisofhinderedamidesviacobaltcatalyzedintermolecularoxidativehydroamidation AT dongchenouyang highlychemoselectivesynthesisofhinderedamidesviacobaltcatalyzedintermolecularoxidativehydroamidation AT qingzhang highlychemoselectivesynthesisofhinderedamidesviacobaltcatalyzedintermolecularoxidativehydroamidation AT rongzhu highlychemoselectivesynthesisofhinderedamidesviacobaltcatalyzedintermolecularoxidativehydroamidation
_version_	1718391186051301376

Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation

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