Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility

Conserved regions of the antibody molecule impact its downstream biological effects. Here the authors show that a rigid hinge conformation increases the agonistic activity of CD40 and DR5 antibodies, distinctly from FcγR-binding, suggesting that the hinge and FcR binding regions can be separately mo...

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Autores principales:	Xiaobo Liu, Yingjie Zhao, Huan Shi, Yan Zhang, Xueying Yin, Mingdong Liu, Huihui Zhang, Yongning He, Boxun Lu, Tengchuan Jin, Fubin Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c93b564f7ca44f88dc22a4f0ce51a3d
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spelling	oai:doaj.org-article:3c93b564f7ca44f88dc22a4f0ce51a3d2021-12-02T17:02:18ZHuman immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility10.1038/s41467-019-12097-62041-1723https://doaj.org/article/3c93b564f7ca44f88dc22a4f0ce51a3d2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12097-6https://doaj.org/toc/2041-1723Conserved regions of the antibody molecule impact its downstream biological effects. Here the authors show that a rigid hinge conformation increases the agonistic activity of CD40 and DR5 antibodies, distinctly from FcγR-binding, suggesting that the hinge and FcR binding regions can be separately modified to optimize therapies.Xiaobo LiuYingjie ZhaoHuan ShiYan ZhangXueying YinMingdong LiuHuihui ZhangYongning HeBoxun LuTengchuan JinFubin LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaobo Liu Yingjie Zhao Huan Shi Yan Zhang Xueying Yin Mingdong Liu Huihui Zhang Yongning He Boxun Lu Tengchuan Jin Fubin Li Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility
description	Conserved regions of the antibody molecule impact its downstream biological effects. Here the authors show that a rigid hinge conformation increases the agonistic activity of CD40 and DR5 antibodies, distinctly from FcγR-binding, suggesting that the hinge and FcR binding regions can be separately modified to optimize therapies.
format	article
author	Xiaobo Liu Yingjie Zhao Huan Shi Yan Zhang Xueying Yin Mingdong Liu Huihui Zhang Yongning He Boxun Lu Tengchuan Jin Fubin Li
author_facet	Xiaobo Liu Yingjie Zhao Huan Shi Yan Zhang Xueying Yin Mingdong Liu Huihui Zhang Yongning He Boxun Lu Tengchuan Jin Fubin Li
author_sort	Xiaobo Liu
title	Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility
title_short	Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility
title_full	Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility
title_fullStr	Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility
title_full_unstemmed	Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility
title_sort	human immunoglobulin g hinge regulates agonistic anti-cd40 immunostimulatory and antitumour activities through biophysical flexibility
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3c93b564f7ca44f88dc22a4f0ce51a3d
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Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility

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