Selectins modify dendritic cells during atherosclerosis

Selectins modify dendritic cells during atherosclerosis

Dendritic cells (DCs) are professional antigen-presenting cells (APC) that facilitate the development and progression of atherosclerosis. However, DCs also function as novel “switches” between immune activation and immune tolerance and represent a heterogeneous hematopoietic lineage, with cell subse...

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Autores principales: Zhi-Shuai Ye, Rong-Chong Huang
Formato: article
Lenguaje:EN
Publicado: KeAi Communications Co., Ltd. 2018
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/3c9589f119a74118924d9223c465e65a
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spelling oai:doaj.org-article:3c9589f119a74118924d9223c465e65a2021-12-02T12:04:35ZSelectins modify dendritic cells during atherosclerosis2095-882X10.1016/j.cdtm.2018.03.001https://doaj.org/article/3c9589f119a74118924d9223c465e65a2018-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X18300100https://doaj.org/toc/2095-882XDendritic cells (DCs) are professional antigen-presenting cells (APC) that facilitate the development and progression of atherosclerosis. However, DCs also function as novel “switches” between immune activation and immune tolerance and represent a heterogeneous hematopoietic lineage, with cell subsets in different tissues that show a differential morphology, phenotype, and function. Regulatory DCs, depending on their immature state, can be induced by immunosuppressive modulation, which plays an important part in the maintenance of immunologic tolerance via suppression of the immune response. In this review, we describe the current understanding of the generation of regulatory DCs. The novel role of selectins in the modification of DCs in atherosclerosis is also discussed. Keywords: Dendritic cells, Selectins, Atherosclerosis, Immune toleranceZhi-Shuai YeRong-Chong HuangKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 4, Iss 4, Pp 205-210 (2018)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Zhi-Shuai Ye
Rong-Chong Huang
Selectins modify dendritic cells during atherosclerosis
description Dendritic cells (DCs) are professional antigen-presenting cells (APC) that facilitate the development and progression of atherosclerosis. However, DCs also function as novel “switches” between immune activation and immune tolerance and represent a heterogeneous hematopoietic lineage, with cell subsets in different tissues that show a differential morphology, phenotype, and function. Regulatory DCs, depending on their immature state, can be induced by immunosuppressive modulation, which plays an important part in the maintenance of immunologic tolerance via suppression of the immune response. In this review, we describe the current understanding of the generation of regulatory DCs. The novel role of selectins in the modification of DCs in atherosclerosis is also discussed. Keywords: Dendritic cells, Selectins, Atherosclerosis, Immune tolerance
format article
author Zhi-Shuai Ye
Rong-Chong Huang
author_facet Zhi-Shuai Ye
Rong-Chong Huang
author_sort Zhi-Shuai Ye
title Selectins modify dendritic cells during atherosclerosis
title_short Selectins modify dendritic cells during atherosclerosis
title_full Selectins modify dendritic cells during atherosclerosis
title_fullStr Selectins modify dendritic cells during atherosclerosis
title_full_unstemmed Selectins modify dendritic cells during atherosclerosis
title_sort selectins modify dendritic cells during atherosclerosis
publisher KeAi Communications Co., Ltd.
publishDate 2018
url https://doaj.org/article/3c9589f119a74118924d9223c465e65a
work_keys_str_mv AT zhishuaiye selectinsmodifydendriticcellsduringatherosclerosis
AT rongchonghuang selectinsmodifydendriticcellsduringatherosclerosis
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