The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger

The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger

Neutrophils are increased in response to injury and infection but how they form from a common granulocyte-macrophage progenitor is unclear. Here, the authors identify a role for the transcriptional repressor ZBTB11 in zebrafish, which is regulated by master myeloid regulators and repressesTP53.

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Autores principales: Maria-Cristina Keightley, Duncan P. Carradice, Judith E. Layton, Luke Pase, Julien Y. Bertrand, Johannes G. Wittig, Aleksandar Dakic, Andrew P. Badrock, Nicholas J. Cole, David Traver, Stephen L. Nutt, Julia McCoey, Ashley M. Buckle, Joan K. Heath, Graham J. Lieschke
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/3c95ab3a3ca641e6961f1263d836b9c2
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spelling oai:doaj.org-article:3c95ab3a3ca641e6961f1263d836b9c22021-12-02T14:42:24ZThe Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger10.1038/ncomms149112041-1723https://doaj.org/article/3c95ab3a3ca641e6961f1263d836b9c22017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14911https://doaj.org/toc/2041-1723Neutrophils are increased in response to injury and infection but how they form from a common granulocyte-macrophage progenitor is unclear. Here, the authors identify a role for the transcriptional repressor ZBTB11 in zebrafish, which is regulated by master myeloid regulators and repressesTP53.Maria-Cristina KeightleyDuncan P. CarradiceJudith E. LaytonLuke PaseJulien Y. BertrandJohannes G. WittigAleksandar DakicAndrew P. BadrockNicholas J. ColeDavid TraverStephen L. NuttJulia McCoeyAshley M. BuckleJoan K. HeathGraham J. LieschkeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Maria-Cristina Keightley
Duncan P. Carradice
Judith E. Layton
Luke Pase
Julien Y. Bertrand
Johannes G. Wittig
Aleksandar Dakic
Andrew P. Badrock
Nicholas J. Cole
David Traver
Stephen L. Nutt
Julia McCoey
Ashley M. Buckle
Joan K. Heath
Graham J. Lieschke
The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger
description Neutrophils are increased in response to injury and infection but how they form from a common granulocyte-macrophage progenitor is unclear. Here, the authors identify a role for the transcriptional repressor ZBTB11 in zebrafish, which is regulated by master myeloid regulators and repressesTP53.
format article
author Maria-Cristina Keightley
Duncan P. Carradice
Judith E. Layton
Luke Pase
Julien Y. Bertrand
Johannes G. Wittig
Aleksandar Dakic
Andrew P. Badrock
Nicholas J. Cole
David Traver
Stephen L. Nutt
Julia McCoey
Ashley M. Buckle
Joan K. Heath
Graham J. Lieschke
author_facet Maria-Cristina Keightley
Duncan P. Carradice
Judith E. Layton
Luke Pase
Julien Y. Bertrand
Johannes G. Wittig
Aleksandar Dakic
Andrew P. Badrock
Nicholas J. Cole
David Traver
Stephen L. Nutt
Julia McCoey
Ashley M. Buckle
Joan K. Heath
Graham J. Lieschke
author_sort Maria-Cristina Keightley
title The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger
title_short The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger
title_full The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger
title_fullStr The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger
title_full_unstemmed The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger
title_sort pu.1 target gene zbtb11 regulates neutrophil development through its integrase-like hhcc zinc finger
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/3c95ab3a3ca641e6961f1263d836b9c2
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