Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex

Lipid droplet biogenesis is orchestrated by the conserved membrane protein Seipin via an unknown mechanism. Here, the authors use structural, biochemical and molecular dynamics simulation approaches to reveal the mechanism of lipid droplet formation by the yeast Seipin Sei1 and its partner Ldb16.

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Autores principales:	Yoel A. Klug, Justin C. Deme, Robin A. Corey, Mike F. Renne, Phillip J. Stansfeld, Susan M. Lea, Pedro Carvalho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c961ba27c154e8598353be409285d56
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spelling	oai:doaj.org-article:3c961ba27c154e8598353be409285d562021-12-02T18:37:28ZMechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex10.1038/s41467-021-26162-62041-1723https://doaj.org/article/3c961ba27c154e8598353be409285d562021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26162-6https://doaj.org/toc/2041-1723Lipid droplet biogenesis is orchestrated by the conserved membrane protein Seipin via an unknown mechanism. Here, the authors use structural, biochemical and molecular dynamics simulation approaches to reveal the mechanism of lipid droplet formation by the yeast Seipin Sei1 and its partner Ldb16.Yoel A. KlugJustin C. DemeRobin A. CoreyMike F. RennePhillip J. StansfeldSusan M. LeaPedro CarvalhoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yoel A. Klug Justin C. Deme Robin A. Corey Mike F. Renne Phillip J. Stansfeld Susan M. Lea Pedro Carvalho Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex
description	Lipid droplet biogenesis is orchestrated by the conserved membrane protein Seipin via an unknown mechanism. Here, the authors use structural, biochemical and molecular dynamics simulation approaches to reveal the mechanism of lipid droplet formation by the yeast Seipin Sei1 and its partner Ldb16.
format	article
author	Yoel A. Klug Justin C. Deme Robin A. Corey Mike F. Renne Phillip J. Stansfeld Susan M. Lea Pedro Carvalho
author_facet	Yoel A. Klug Justin C. Deme Robin A. Corey Mike F. Renne Phillip J. Stansfeld Susan M. Lea Pedro Carvalho
author_sort	Yoel A. Klug
title	Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex
title_short	Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex
title_full	Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex
title_fullStr	Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex
title_full_unstemmed	Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex
title_sort	mechanism of lipid droplet formation by the yeast sei1/ldb16 seipin complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3c961ba27c154e8598353be409285d56
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Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex

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