Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden

Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden

Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is predictive of ctDNA burden.

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Detalles Bibliográficos
Autores principales: Guanhua Zhu, Yu A. Guo, Danliang Ho, Polly Poon, Zhong Wee Poh, Pui Mun Wong, Anna Gan, Mei Mei Chang, Dimitrios Kleftogiannis, Yi Ting Lau, Brenda Tay, Wan Jun Lim, Clarinda Chua, Tira J. Tan, Si-Lin Koo, Dawn Q. Chong, Yoon Sim Yap, Iain Tan, Sarah Ng, Anders J. Skanderup
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
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Acceso en línea:https://doaj.org/article/3c974350bb8a41b0a12aa9c3b0c56857
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Descripción
Sumario:Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is predictive of ctDNA burden.

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