Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden

Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is predictive of ctDNA burden.

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Autores principales:	Guanhua Zhu, Yu A. Guo, Danliang Ho, Polly Poon, Zhong Wee Poh, Pui Mun Wong, Anna Gan, Mei Mei Chang, Dimitrios Kleftogiannis, Yi Ting Lau, Brenda Tay, Wan Jun Lim, Clarinda Chua, Tira J. Tan, Si-Lin Koo, Dawn Q. Chong, Yoon Sim Yap, Iain Tan, Sarah Ng, Anders J. Skanderup
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c974350bb8a41b0a12aa9c3b0c56857
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spelling	oai:doaj.org-article:3c974350bb8a41b0a12aa9c3b0c568572021-12-02T18:03:26ZTissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden10.1038/s41467-021-22463-y2041-1723https://doaj.org/article/3c974350bb8a41b0a12aa9c3b0c568572021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22463-yhttps://doaj.org/toc/2041-1723Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is predictive of ctDNA burden.Guanhua ZhuYu A. GuoDanliang HoPolly PoonZhong Wee PohPui Mun WongAnna GanMei Mei ChangDimitrios KleftogiannisYi Ting LauBrenda TayWan Jun LimClarinda ChuaTira J. TanSi-Lin KooDawn Q. ChongYoon Sim YapIain TanSarah NgAnders J. SkanderupNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guanhua Zhu Yu A. Guo Danliang Ho Polly Poon Zhong Wee Poh Pui Mun Wong Anna Gan Mei Mei Chang Dimitrios Kleftogiannis Yi Ting Lau Brenda Tay Wan Jun Lim Clarinda Chua Tira J. Tan Si-Lin Koo Dawn Q. Chong Yoon Sim Yap Iain Tan Sarah Ng Anders J. Skanderup Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden
description	Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is predictive of ctDNA burden.
format	article
author	Guanhua Zhu Yu A. Guo Danliang Ho Polly Poon Zhong Wee Poh Pui Mun Wong Anna Gan Mei Mei Chang Dimitrios Kleftogiannis Yi Ting Lau Brenda Tay Wan Jun Lim Clarinda Chua Tira J. Tan Si-Lin Koo Dawn Q. Chong Yoon Sim Yap Iain Tan Sarah Ng Anders J. Skanderup
author_facet	Guanhua Zhu Yu A. Guo Danliang Ho Polly Poon Zhong Wee Poh Pui Mun Wong Anna Gan Mei Mei Chang Dimitrios Kleftogiannis Yi Ting Lau Brenda Tay Wan Jun Lim Clarinda Chua Tira J. Tan Si-Lin Koo Dawn Q. Chong Yoon Sim Yap Iain Tan Sarah Ng Anders J. Skanderup
author_sort	Guanhua Zhu
title	Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden
title_short	Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden
title_full	Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden
title_fullStr	Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden
title_full_unstemmed	Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden
title_sort	tissue-specific cell-free dna degradation quantifies circulating tumor dna burden
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3c974350bb8a41b0a12aa9c3b0c56857
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Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden

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