Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden
Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is predictive of ctDNA burden.
Guardado en:
Autores principales: | Guanhua Zhu, Yu A. Guo, Danliang Ho, Polly Poon, Zhong Wee Poh, Pui Mun Wong, Anna Gan, Mei Mei Chang, Dimitrios Kleftogiannis, Yi Ting Lau, Brenda Tay, Wan Jun Lim, Clarinda Chua, Tira J. Tan, Si-Lin Koo, Dawn Q. Chong, Yoon Sim Yap, Iain Tan, Sarah Ng, Anders J. Skanderup |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/3c974350bb8a41b0a12aa9c3b0c56857 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Author Correction: Mitochondrial DNA alterations may influence the cisplatin responsiveness of oral squamous cell carcinoma
por: Amnani Aminuddin, et al.
Publicado: (2021) -
Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos
por: Rosemary H. C. Wilson, et al.
Publicado: (2017) -
The DnaK/DnaJ Chaperone System Enables RNA Polymerase-DksA Complex Formation in Salmonella Experiencing Oxidative Stress
por: Ju-Sim Kim, et al.
Publicado: (2021) -
Gold nanocrystals with DNA-directed morphologies
por: Xingyi Ma, et al.
Publicado: (2016) -
Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers
por: Yu Amanda Guo, et al.
Publicado: (2018)