STAT-5 Regulates Transcription of the Topoisomerase IIβ-Binding Protein 1 (TopBP1) Gene To Activate the ATR Pathway and Promote Human Papillomavirus Replication

ABSTRACT The life cycle of high-risk human papillomaviruses (HPVs) is dependent upon epithelial differentiation. Following infection of basal cells, HPV genomes are stably maintained at low copy numbers, and productive replication or amplification is restricted to highly differentiated suprabasal ce...

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Bibliographic Details
Main Authors: Shiyuan Hong, Shouqiang Cheng, Andre Iovane, Laimonis A. Laimins
Format: article
Language:EN
Published: American Society for Microbiology 2015
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Online Access:https://doaj.org/article/3c9b0d4e0994485684d093a2d582d9a0
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