Technology update: dissolvable microneedle patches for vaccine delivery

Aoife M Rodgers, Ana Sara Cordeiro, Ryan F Donnelly School of Pharmacy, Queen’s University Belfast, Belfast, BT9 7BL, UKCorrespondence: Ryan F DonnellySchool of Pharmacy, Queen’s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UKTel +44 289 097 2251F...

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Autores principales:	Rodgers AM, Cordeiro AS, Donnelly RF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Microneedle patches dissolvable vaccine cold-chain hazardous sharps waste skin. Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/3c9bfc251b184af19bd9b07ce45bafbd
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spelling	oai:doaj.org-article:3c9bfc251b184af19bd9b07ce45bafbd2021-12-02T04:06:33ZTechnology update: dissolvable microneedle patches for vaccine delivery1179-1470https://doaj.org/article/3c9bfc251b184af19bd9b07ce45bafbd2019-09-01T00:00:00Zhttps://www.dovepress.com/technology-update-dissolvable-microneedle-patches-for-vaccine-delivery-peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470Aoife M Rodgers, Ana Sara Cordeiro, Ryan F Donnelly School of Pharmacy, Queen’s University Belfast, Belfast, BT9 7BL, UKCorrespondence: Ryan F DonnellySchool of Pharmacy, Queen’s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UKTel +44 289 097 2251Fax +44 289 024 7794Email r.donnelly@qub.ac.ukAbstract: Despite vaccination representing one of the greatest advances of modern preventative medicine, there remain significant challenges in vaccine distribution, delivery and compliance. Dissolvable microarray patches or dissolving microneedles (DMN) have been proposed as an innovative vaccine delivery platform that could potentially revolutionize vaccine delivery and circumvent many of the challenges faced with current vaccine strategies. DMN, due to their ease of use, lack of elicitation of pain response, self-disabling nature and ease of transport and distribution, offer an attractive delivery option for vaccines. Additionally, as DMN inherently targets the uppermost skin layers, they facilitate improved vaccine efficacy, due to direct targeting of skin antigen-presenting cells. A plethora of publications have demonstrated the efficacy of DMN vaccination for a range of vaccines, with influenza receiving particular attention. However, before the viable adoption of DMN for vaccination purposes in a clinical setting, a number of fundamental questions must be addressed. Accordingly, this review begins by introducing some of the key barriers faced by current vaccination approaches and how DMN can overcome these challenges. We introduce some of the recent advances in the field of DMN technology, highlighting the potential impact DMN could have, particularly in countries of the developing world. We conclude by reflecting on some of the key questions that remain unanswered and which warrant further investigation before DMNs can be utilized in clinical settings.Keywords: microneedle patches, dissolvable, vaccine, cold chain, hazardous sharps waste, skinRodgers AMCordeiro ASDonnelly RFDove Medical PressarticleMicroneedle patchesdissolvablevaccinecold-chainhazardous sharps wasteskin.Medical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol Volume 12, Pp 379-398 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microneedle patches dissolvable vaccine cold-chain hazardous sharps waste skin. Medical technology R855-855.5
spellingShingle	Microneedle patches dissolvable vaccine cold-chain hazardous sharps waste skin. Medical technology R855-855.5 Rodgers AM Cordeiro AS Donnelly RF Technology update: dissolvable microneedle patches for vaccine delivery
description	Aoife M Rodgers, Ana Sara Cordeiro, Ryan F Donnelly School of Pharmacy, Queen’s University Belfast, Belfast, BT9 7BL, UKCorrespondence: Ryan F DonnellySchool of Pharmacy, Queen’s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UKTel +44 289 097 2251Fax +44 289 024 7794Email r.donnelly@qub.ac.ukAbstract: Despite vaccination representing one of the greatest advances of modern preventative medicine, there remain significant challenges in vaccine distribution, delivery and compliance. Dissolvable microarray patches or dissolving microneedles (DMN) have been proposed as an innovative vaccine delivery platform that could potentially revolutionize vaccine delivery and circumvent many of the challenges faced with current vaccine strategies. DMN, due to their ease of use, lack of elicitation of pain response, self-disabling nature and ease of transport and distribution, offer an attractive delivery option for vaccines. Additionally, as DMN inherently targets the uppermost skin layers, they facilitate improved vaccine efficacy, due to direct targeting of skin antigen-presenting cells. A plethora of publications have demonstrated the efficacy of DMN vaccination for a range of vaccines, with influenza receiving particular attention. However, before the viable adoption of DMN for vaccination purposes in a clinical setting, a number of fundamental questions must be addressed. Accordingly, this review begins by introducing some of the key barriers faced by current vaccination approaches and how DMN can overcome these challenges. We introduce some of the recent advances in the field of DMN technology, highlighting the potential impact DMN could have, particularly in countries of the developing world. We conclude by reflecting on some of the key questions that remain unanswered and which warrant further investigation before DMNs can be utilized in clinical settings.Keywords: microneedle patches, dissolvable, vaccine, cold chain, hazardous sharps waste, skin
format	article
author	Rodgers AM Cordeiro AS Donnelly RF
author_facet	Rodgers AM Cordeiro AS Donnelly RF
author_sort	Rodgers AM
title	Technology update: dissolvable microneedle patches for vaccine delivery
title_short	Technology update: dissolvable microneedle patches for vaccine delivery
title_full	Technology update: dissolvable microneedle patches for vaccine delivery
title_fullStr	Technology update: dissolvable microneedle patches for vaccine delivery
title_full_unstemmed	Technology update: dissolvable microneedle patches for vaccine delivery
title_sort	technology update: dissolvable microneedle patches for vaccine delivery
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/3c9bfc251b184af19bd9b07ce45bafbd
work_keys_str_mv	AT rodgersam technologyupdatedissolvablemicroneedlepatchesforvaccinedelivery AT cordeiroas technologyupdatedissolvablemicroneedlepatchesforvaccinedelivery AT donnellyrf technologyupdatedissolvablemicroneedlepatchesforvaccinedelivery
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Technology update: dissolvable microneedle patches for vaccine delivery

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