Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer
BackgroundPrevious study implicated that genes of matrix metalloproteinase (MMP) family play an important role in tumor invasion, neoangiogenesis, and metastasis. However, the diverse expression patterns and prognostic values of 24 MMPs in colorectal cancer are yet to be analyzed.MethodsIn this stud...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:3c9ee136d163405588785399b68cbec52021-11-05T05:48:15ZComprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer2234-943X10.3389/fonc.2021.771099https://doaj.org/article/3c9ee136d163405588785399b68cbec52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.771099/fullhttps://doaj.org/toc/2234-943XBackgroundPrevious study implicated that genes of matrix metalloproteinase (MMP) family play an important role in tumor invasion, neoangiogenesis, and metastasis. However, the diverse expression patterns and prognostic values of 24 MMPs in colorectal cancer are yet to be analyzed.MethodsIn this study, by integrating public database and our data, we first investigated the expression levels and protein levels of MMPs in patients with colorectal cancer. Then, by using TCGA and GEO datasets, we evaluated the association of MMPs with clinicopathological parameters and prognosis of colorectal cancer. Finally, by using the cBioPortal online tool, we analyzed the alterations of MMPs and did the network and pathway analyses for MMPs and their nearby genes.ResultsWe found that, MMP1, MMP3, MMP7, MMP9–MMP12, and MMP14 were consistently upregulated in public dataset and our samples. Whereas, MMP28 was consistently downregulated in public dataset and our samples. In the clinicopathological analyses, upregulated MMP11, MMP14, MMP16, MMP17, MMP19, and MMP23B were significantly associated with a higher tumor stage. In the survival analyses, upregulated MMP11, MMP14, MMP17, and MMP19 were significantly associated with a shorter progression-free survival (PFS) time and a shorter relapse-free (RFS) time.DiscussionThis study implied that MMP11, MMP14, MMP17, and MMP19 are potential targets of precision therapy for patients with colorectal cancer.Jing YuJing YuZhen HeZhen HeXiaowen HeXiaowen HeZhanhao LuoLei LianLei LianBaixing WuPing LanPing LanHaitao ChenHaitao ChenFrontiers Media S.A.articlecolorectal cancerMMPsprognosisexpressiontumor stageNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
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EN |
| topic |
colorectal cancer MMPs prognosis expression tumor stage Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
colorectal cancer MMPs prognosis expression tumor stage Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jing Yu Jing Yu Zhen He Zhen He Xiaowen He Xiaowen He Zhanhao Luo Lei Lian Lei Lian Baixing Wu Ping Lan Ping Lan Haitao Chen Haitao Chen Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer |
| description |
BackgroundPrevious study implicated that genes of matrix metalloproteinase (MMP) family play an important role in tumor invasion, neoangiogenesis, and metastasis. However, the diverse expression patterns and prognostic values of 24 MMPs in colorectal cancer are yet to be analyzed.MethodsIn this study, by integrating public database and our data, we first investigated the expression levels and protein levels of MMPs in patients with colorectal cancer. Then, by using TCGA and GEO datasets, we evaluated the association of MMPs with clinicopathological parameters and prognosis of colorectal cancer. Finally, by using the cBioPortal online tool, we analyzed the alterations of MMPs and did the network and pathway analyses for MMPs and their nearby genes.ResultsWe found that, MMP1, MMP3, MMP7, MMP9–MMP12, and MMP14 were consistently upregulated in public dataset and our samples. Whereas, MMP28 was consistently downregulated in public dataset and our samples. In the clinicopathological analyses, upregulated MMP11, MMP14, MMP16, MMP17, MMP19, and MMP23B were significantly associated with a higher tumor stage. In the survival analyses, upregulated MMP11, MMP14, MMP17, and MMP19 were significantly associated with a shorter progression-free survival (PFS) time and a shorter relapse-free (RFS) time.DiscussionThis study implied that MMP11, MMP14, MMP17, and MMP19 are potential targets of precision therapy for patients with colorectal cancer. |
| format |
article |
| author |
Jing Yu Jing Yu Zhen He Zhen He Xiaowen He Xiaowen He Zhanhao Luo Lei Lian Lei Lian Baixing Wu Ping Lan Ping Lan Haitao Chen Haitao Chen |
| author_facet |
Jing Yu Jing Yu Zhen He Zhen He Xiaowen He Xiaowen He Zhanhao Luo Lei Lian Lei Lian Baixing Wu Ping Lan Ping Lan Haitao Chen Haitao Chen |
| author_sort |
Jing Yu |
| title |
Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer |
| title_short |
Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer |
| title_full |
Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer |
| title_fullStr |
Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer |
| title_full_unstemmed |
Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer |
| title_sort |
comprehensive analysis of the expression and prognosis for mmps in human colorectal cancer |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/3c9ee136d163405588785399b68cbec5 |
| work_keys_str_mv |
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1718444463837151232 |