Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats

Abstract Background Recent studies show that gender may have a significant impact on brain functions. However, the reports of sex effects on spatial ability and synaptic plasticity in rodents are divergent and controversial. Here spatial learning and memory was measured in male and female rats by us...

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Autores principales:	Samaneh Safari, Nesa Ahmadi, Reihaneh Mohammadkhani, Reza Ghahremani, Maryam Khajvand-Abedeni, Siamak Shahidi, Alireza Komaki, Iraj Salehi, Seyed Asaad Karimi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Long-term potentiation Hippocampus Dentate Gyrus, Spatial learning and memory Sex difference Wistar Rat Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/3ca4165055c1474a8215b940243de302
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spelling	oai:doaj.org-article:3ca4165055c1474a8215b940243de3022021-11-07T12:04:01ZSex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats10.1186/s12993-021-00184-y1744-9081https://doaj.org/article/3ca4165055c1474a8215b940243de3022021-11-01T00:00:00Zhttps://doi.org/10.1186/s12993-021-00184-yhttps://doaj.org/toc/1744-9081Abstract Background Recent studies show that gender may have a significant impact on brain functions. However, the reports of sex effects on spatial ability and synaptic plasticity in rodents are divergent and controversial. Here spatial learning and memory was measured in male and female rats by using Morris water maze (MWM) task. Moreover, to assess sex difference in hippocampal synaptic plasticity we examined hippocampal long-term potentiation (LTP) at perforant pathway-dentate gyrus (PP-DG) synapses. Results In MWM task, male rats outperformed female rats, as they had significantly shorter swim distance and escape latency to find the hidden platform during training days. During spatial reference memory test, female rats spent less time and traveled less distance in the target zone. Male rats also had larger LTP at PP-DG synapses, which was evident in the high magnitude of population spike (PS) potentiation and the field excitatory post synaptic potentials (fEPSP) slope. Conclusions Taken together, our results suggest that sex differences in the LTP at PP-DG synapses, possibly contribute to the observed sex difference in spatial learning and memory.Samaneh SafariNesa AhmadiReihaneh MohammadkhaniReza GhahremaniMaryam Khajvand-AbedeniSiamak ShahidiAlireza KomakiIraj SalehiSeyed Asaad KarimiBMCarticleLong-term potentiationHippocampusDentate Gyrus, Spatial learning and memorySex differenceWistar RatNeurology. Diseases of the nervous systemRC346-429ENBehavioral and Brain Functions, Vol 17, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Long-term potentiation Hippocampus Dentate Gyrus, Spatial learning and memory Sex difference Wistar Rat Neurology. Diseases of the nervous system RC346-429
spellingShingle	Long-term potentiation Hippocampus Dentate Gyrus, Spatial learning and memory Sex difference Wistar Rat Neurology. Diseases of the nervous system RC346-429 Samaneh Safari Nesa Ahmadi Reihaneh Mohammadkhani Reza Ghahremani Maryam Khajvand-Abedeni Siamak Shahidi Alireza Komaki Iraj Salehi Seyed Asaad Karimi Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats
description	Abstract Background Recent studies show that gender may have a significant impact on brain functions. However, the reports of sex effects on spatial ability and synaptic plasticity in rodents are divergent and controversial. Here spatial learning and memory was measured in male and female rats by using Morris water maze (MWM) task. Moreover, to assess sex difference in hippocampal synaptic plasticity we examined hippocampal long-term potentiation (LTP) at perforant pathway-dentate gyrus (PP-DG) synapses. Results In MWM task, male rats outperformed female rats, as they had significantly shorter swim distance and escape latency to find the hidden platform during training days. During spatial reference memory test, female rats spent less time and traveled less distance in the target zone. Male rats also had larger LTP at PP-DG synapses, which was evident in the high magnitude of population spike (PS) potentiation and the field excitatory post synaptic potentials (fEPSP) slope. Conclusions Taken together, our results suggest that sex differences in the LTP at PP-DG synapses, possibly contribute to the observed sex difference in spatial learning and memory.
format	article
author	Samaneh Safari Nesa Ahmadi Reihaneh Mohammadkhani Reza Ghahremani Maryam Khajvand-Abedeni Siamak Shahidi Alireza Komaki Iraj Salehi Seyed Asaad Karimi
author_facet	Samaneh Safari Nesa Ahmadi Reihaneh Mohammadkhani Reza Ghahremani Maryam Khajvand-Abedeni Siamak Shahidi Alireza Komaki Iraj Salehi Seyed Asaad Karimi
author_sort	Samaneh Safari
title	Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats
title_short	Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats
title_full	Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats
title_fullStr	Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats
title_full_unstemmed	Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats
title_sort	sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (pp-dg) synapses in wistar rats
publisher	BMC
publishDate	2021
url	https://doaj.org/article/3ca4165055c1474a8215b940243de302
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Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats

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