Impaired visual working memory and reduced connectivity in undergraduates with a history of mild traumatic brain injury

Abstract Mild traumatic brain injury (mTBI), or concussion, accounts for 85% of all TBIs. Yet survivors anticipate full cognitive recovery within several months of injury, if not sooner, dependent upon the specific outcome/measure. Recovery is variable and deficits in executive function, e.g., worki...

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Autores principales:	Hector Arciniega, Jorja Shires, Sarah Furlong, Alexandrea Kilgore-Gomez, Adelle Cerreta, Nicholas G. Murray, Marian E. Berryhill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ca48b11d7fc46048cd7070cf33482cb
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spelling	oai:doaj.org-article:3ca48b11d7fc46048cd7070cf33482cb2021-12-02T14:06:50ZImpaired visual working memory and reduced connectivity in undergraduates with a history of mild traumatic brain injury10.1038/s41598-021-80995-12045-2322https://doaj.org/article/3ca48b11d7fc46048cd7070cf33482cb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-80995-1https://doaj.org/toc/2045-2322Abstract Mild traumatic brain injury (mTBI), or concussion, accounts for 85% of all TBIs. Yet survivors anticipate full cognitive recovery within several months of injury, if not sooner, dependent upon the specific outcome/measure. Recovery is variable and deficits in executive function, e.g., working memory (WM) can persist years post-mTBI. We tested whether cognitive deficits persist in otherwise healthy undergraduates, as a conservative indicator for mTBI survivors at large. We collected WM performance (change detection, n-back tasks) using various stimuli (shapes, locations, letters; aurally presented numbers and letters), and wide-ranging cognitive assessments (e.g., RBANS). We replicated the observation of a general visual WM deficit, with preserved auditory WM. Surprisingly, visual WM deficits were equivalent in participants with a history of mTBI (mean 4.3 years post-injury) and in undergraduates with recent sports-related mTBI (mean 17 days post-injury). In seeking the underlying mechanism of these behavioral deficits, we collected resting state fMRI (rsfMRI) and EEG (rsEEG). RsfMRI revealed significantly reduced connectivity within WM-relevant networks (default mode, central executive, dorsal attention, salience), whereas rsEEG identified no differences (modularity, global efficiency, local efficiency). In summary, otherwise healthy current undergraduates with a history of mTBI present behavioral deficits with evidence of persistent disconnection long after full recovery is expected.Hector ArciniegaJorja ShiresSarah FurlongAlexandrea Kilgore-GomezAdelle CerretaNicholas G. MurrayMarian E. BerryhillNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hector Arciniega Jorja Shires Sarah Furlong Alexandrea Kilgore-Gomez Adelle Cerreta Nicholas G. Murray Marian E. Berryhill Impaired visual working memory and reduced connectivity in undergraduates with a history of mild traumatic brain injury
description	Abstract Mild traumatic brain injury (mTBI), or concussion, accounts for 85% of all TBIs. Yet survivors anticipate full cognitive recovery within several months of injury, if not sooner, dependent upon the specific outcome/measure. Recovery is variable and deficits in executive function, e.g., working memory (WM) can persist years post-mTBI. We tested whether cognitive deficits persist in otherwise healthy undergraduates, as a conservative indicator for mTBI survivors at large. We collected WM performance (change detection, n-back tasks) using various stimuli (shapes, locations, letters; aurally presented numbers and letters), and wide-ranging cognitive assessments (e.g., RBANS). We replicated the observation of a general visual WM deficit, with preserved auditory WM. Surprisingly, visual WM deficits were equivalent in participants with a history of mTBI (mean 4.3 years post-injury) and in undergraduates with recent sports-related mTBI (mean 17 days post-injury). In seeking the underlying mechanism of these behavioral deficits, we collected resting state fMRI (rsfMRI) and EEG (rsEEG). RsfMRI revealed significantly reduced connectivity within WM-relevant networks (default mode, central executive, dorsal attention, salience), whereas rsEEG identified no differences (modularity, global efficiency, local efficiency). In summary, otherwise healthy current undergraduates with a history of mTBI present behavioral deficits with evidence of persistent disconnection long after full recovery is expected.
format	article
author	Hector Arciniega Jorja Shires Sarah Furlong Alexandrea Kilgore-Gomez Adelle Cerreta Nicholas G. Murray Marian E. Berryhill
author_facet	Hector Arciniega Jorja Shires Sarah Furlong Alexandrea Kilgore-Gomez Adelle Cerreta Nicholas G. Murray Marian E. Berryhill
author_sort	Hector Arciniega
title	Impaired visual working memory and reduced connectivity in undergraduates with a history of mild traumatic brain injury
title_short	Impaired visual working memory and reduced connectivity in undergraduates with a history of mild traumatic brain injury
title_full	Impaired visual working memory and reduced connectivity in undergraduates with a history of mild traumatic brain injury
title_fullStr	Impaired visual working memory and reduced connectivity in undergraduates with a history of mild traumatic brain injury
title_full_unstemmed	Impaired visual working memory and reduced connectivity in undergraduates with a history of mild traumatic brain injury
title_sort	impaired visual working memory and reduced connectivity in undergraduates with a history of mild traumatic brain injury
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3ca48b11d7fc46048cd7070cf33482cb
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Impaired visual working memory and reduced connectivity in undergraduates with a history of mild traumatic brain injury

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