m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2

Several functions have been proposed for m6A in RNA metabolism, yet little is known regarding the specific functions of individual m6A readers. Here, the authors observe that the m6A reader YTHDC2 — which contains an RNA helicase domain — acts on the coding region to promotes mRNA translation by res...

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Autores principales:	Yuanhui Mao, Leiming Dong, Xiao-Min Liu, Jiayin Guo, Honghui Ma, Bin Shen, Shu-Bing Qian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3ca83b1462a8473fb1ee44b8fa43183d
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spelling	oai:doaj.org-article:3ca83b1462a8473fb1ee44b8fa43183d2021-12-02T16:57:54Zm6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC210.1038/s41467-019-13317-92041-1723https://doaj.org/article/3ca83b1462a8473fb1ee44b8fa43183d2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13317-9https://doaj.org/toc/2041-1723Several functions have been proposed for m6A in RNA metabolism, yet little is known regarding the specific functions of individual m6A readers. Here, the authors observe that the m6A reader YTHDC2 — which contains an RNA helicase domain — acts on the coding region to promotes mRNA translation by resolving secondary structures.Yuanhui MaoLeiming DongXiao-Min LiuJiayin GuoHonghui MaBin ShenShu-Bing QianNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuanhui Mao Leiming Dong Xiao-Min Liu Jiayin Guo Honghui Ma Bin Shen Shu-Bing Qian m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
description	Several functions have been proposed for m6A in RNA metabolism, yet little is known regarding the specific functions of individual m6A readers. Here, the authors observe that the m6A reader YTHDC2 — which contains an RNA helicase domain — acts on the coding region to promotes mRNA translation by resolving secondary structures.
format	article
author	Yuanhui Mao Leiming Dong Xiao-Min Liu Jiayin Guo Honghui Ma Bin Shen Shu-Bing Qian
author_facet	Yuanhui Mao Leiming Dong Xiao-Min Liu Jiayin Guo Honghui Ma Bin Shen Shu-Bing Qian
author_sort	Yuanhui Mao
title	m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
title_short	m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
title_full	m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
title_fullStr	m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
title_full_unstemmed	m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
title_sort	m6a in mrna coding regions promotes translation via the rna helicase-containing ythdc2
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3ca83b1462a8473fb1ee44b8fa43183d
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m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2

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