Chemically cross-linked silk fibroin hydrogel with enhanced elastic properties, biodegradability, and biocompatibility

Min Hee Kim, Won Ho Park Department of Advanced Organic Materials and Textile Engineering System, Chungnam National University, Daejeon, Korea Abstract: In this study, the synthesis of silk fibroin (SF) hydrogel via chemical cross-linking reactions of SF due to gamma-ray (γ-ray) irradiat...

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Autores principales:	Kim MH, Park WH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	silk fibroin hydrogels biodegradation rate gamma irradiation crosslinking Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3caa51fe1f2643968cc65c4a3f747a4d
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spelling	oai:doaj.org-article:3caa51fe1f2643968cc65c4a3f747a4d2021-12-02T05:36:19ZChemically cross-linked silk fibroin hydrogel with enhanced elastic properties, biodegradability, and biocompatibility1178-2013https://doaj.org/article/3caa51fe1f2643968cc65c4a3f747a4d2016-06-01T00:00:00Zhttps://www.dovepress.com/chemically-cross-linked-silk-fibroin-hydrogel-with-enhanced-elastic-pr-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Min Hee Kim, Won Ho Park Department of Advanced Organic Materials and Textile Engineering System, Chungnam National University, Daejeon, Korea Abstract: In this study, the synthesis of silk fibroin (SF) hydrogel via chemical cross-linking reactions of SF due to gamma-ray (γ-ray) irradiation was investigated, as were the resultant hydrogel’s properties. Two different hydrogels were investigated: physically cross-linked SF hydrogel and chemically cross-linked SF hydrogel irradiated at different doses of γ-rays. The effects of the irradiation dose and SF concentration on the hydrogelation of SF were examined. The chemically cross-linked SF hydrogel was compared with the physically cross-linked one with regard to secondary structure and gel strength. Furthermore, the swelling behavior, crystallinity, and biodegradation of the SF hydrogels were characterized. To assay cell proliferation, the cell viability of human mesenchymal stem cells on the lyophilized SF hydrogel scaffolds was evaluated, and no significant cytotoxicity against human mesenchymal stem cells was observed. Keywords: silk fibroin, hydrogels, biodegradation rate, gamma irradiation, cross-linkingKim MHPark WHDove Medical Pressarticlesilk fibroinhydrogelsbiodegradation rategamma irradiationcrosslinkingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2967-2978 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	silk fibroin hydrogels biodegradation rate gamma irradiation crosslinking Medicine (General) R5-920
spellingShingle	silk fibroin hydrogels biodegradation rate gamma irradiation crosslinking Medicine (General) R5-920 Kim MH Park WH Chemically cross-linked silk fibroin hydrogel with enhanced elastic properties, biodegradability, and biocompatibility
description	Min Hee Kim, Won Ho Park Department of Advanced Organic Materials and Textile Engineering System, Chungnam National University, Daejeon, Korea Abstract: In this study, the synthesis of silk fibroin (SF) hydrogel via chemical cross-linking reactions of SF due to gamma-ray (γ-ray) irradiation was investigated, as were the resultant hydrogel’s properties. Two different hydrogels were investigated: physically cross-linked SF hydrogel and chemically cross-linked SF hydrogel irradiated at different doses of γ-rays. The effects of the irradiation dose and SF concentration on the hydrogelation of SF were examined. The chemically cross-linked SF hydrogel was compared with the physically cross-linked one with regard to secondary structure and gel strength. Furthermore, the swelling behavior, crystallinity, and biodegradation of the SF hydrogels were characterized. To assay cell proliferation, the cell viability of human mesenchymal stem cells on the lyophilized SF hydrogel scaffolds was evaluated, and no significant cytotoxicity against human mesenchymal stem cells was observed. Keywords: silk fibroin, hydrogels, biodegradation rate, gamma irradiation, cross-linking
format	article
author	Kim MH Park WH
author_facet	Kim MH Park WH
author_sort	Kim MH
title	Chemically cross-linked silk fibroin hydrogel with enhanced elastic properties, biodegradability, and biocompatibility
title_short	Chemically cross-linked silk fibroin hydrogel with enhanced elastic properties, biodegradability, and biocompatibility
title_full	Chemically cross-linked silk fibroin hydrogel with enhanced elastic properties, biodegradability, and biocompatibility
title_fullStr	Chemically cross-linked silk fibroin hydrogel with enhanced elastic properties, biodegradability, and biocompatibility
title_full_unstemmed	Chemically cross-linked silk fibroin hydrogel with enhanced elastic properties, biodegradability, and biocompatibility
title_sort	chemically cross-linked silk fibroin hydrogel with enhanced elastic properties, biodegradability, and biocompatibility
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/3caa51fe1f2643968cc65c4a3f747a4d
work_keys_str_mv	AT kimmh chemicallycrosslinkedsilkfibroinhydrogelwithenhancedelasticpropertiesbiodegradabilityandbiocompatibility AT parkwh chemicallycrosslinkedsilkfibroinhydrogelwithenhancedelasticpropertiesbiodegradabilityandbiocompatibility
_version_	1718400290433007616

Chemically cross-linked silk fibroin hydrogel with enhanced elastic properties, biodegradability, and biocompatibility

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