Emergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients.

Streptococcus agalactiae is a well-known pathogen for neonates and immunocompromized adults. Beyond the neonatal period, S. agalactiae is rarely found in the respiratory tract. During 2002-2008 we noticed S. agalactiae in respiratory secretions of 30/185 (16%) of cystic fibrosis (CF) patients. The m...

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Autores principales:	Vera Eickel, Barbara Kahl, Beatrice Reinisch, Angelika Dübbers, Peter Küster, Claudia Brandt, Barbara Spellerberg
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3cad0a680d2e4262aefe016cdf1c3085
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spelling	oai:doaj.org-article:3cad0a680d2e4262aefe016cdf1c30852021-11-25T06:17:03ZEmergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients.1932-620310.1371/journal.pone.0004650https://doaj.org/article/3cad0a680d2e4262aefe016cdf1c30852009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19247473/?tool=EBIhttps://doaj.org/toc/1932-6203Streptococcus agalactiae is a well-known pathogen for neonates and immunocompromized adults. Beyond the neonatal period, S. agalactiae is rarely found in the respiratory tract. During 2002-2008 we noticed S. agalactiae in respiratory secretions of 30/185 (16%) of cystic fibrosis (CF) patients. The median age of these patients was 3-6 years older than the median age CF patients not harboring S. agalactiae. To analyze, if the S. agalactiae isolates from CF patients were clonal, further characterization of the strains was achieved by capsular serotyping, surface protein determination and multilocus sequence typing (MLST). We found a variety of sequence types (ST) among the isolates, which did not substantially differ from the MLST patterns of colonizing strains from Germany. However serotype III, which is often seen in colonizing strains and invasive infections was rare among CF patients. The emergence of S. agalactiae in the respiratory tract of CF patients may represent the adaptation to a novel host environment, supported by the altered surfactant composition in older CF patients.Vera EickelBarbara KahlBeatrice ReinischAngelika DübbersPeter KüsterClaudia BrandtBarbara SpellerbergPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 2, p e4650 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vera Eickel Barbara Kahl Beatrice Reinisch Angelika Dübbers Peter Küster Claudia Brandt Barbara Spellerberg Emergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients.
description	Streptococcus agalactiae is a well-known pathogen for neonates and immunocompromized adults. Beyond the neonatal period, S. agalactiae is rarely found in the respiratory tract. During 2002-2008 we noticed S. agalactiae in respiratory secretions of 30/185 (16%) of cystic fibrosis (CF) patients. The median age of these patients was 3-6 years older than the median age CF patients not harboring S. agalactiae. To analyze, if the S. agalactiae isolates from CF patients were clonal, further characterization of the strains was achieved by capsular serotyping, surface protein determination and multilocus sequence typing (MLST). We found a variety of sequence types (ST) among the isolates, which did not substantially differ from the MLST patterns of colonizing strains from Germany. However serotype III, which is often seen in colonizing strains and invasive infections was rare among CF patients. The emergence of S. agalactiae in the respiratory tract of CF patients may represent the adaptation to a novel host environment, supported by the altered surfactant composition in older CF patients.
format	article
author	Vera Eickel Barbara Kahl Beatrice Reinisch Angelika Dübbers Peter Küster Claudia Brandt Barbara Spellerberg
author_facet	Vera Eickel Barbara Kahl Beatrice Reinisch Angelika Dübbers Peter Küster Claudia Brandt Barbara Spellerberg
author_sort	Vera Eickel
title	Emergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients.
title_short	Emergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients.
title_full	Emergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients.
title_fullStr	Emergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients.
title_full_unstemmed	Emergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients.
title_sort	emergence of respiratory streptococcus agalactiae isolates in cystic fibrosis patients.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/3cad0a680d2e4262aefe016cdf1c3085
work_keys_str_mv	AT veraeickel emergenceofrespiratorystreptococcusagalactiaeisolatesincysticfibrosispatients AT barbarakahl emergenceofrespiratorystreptococcusagalactiaeisolatesincysticfibrosispatients AT beatricereinisch emergenceofrespiratorystreptococcusagalactiaeisolatesincysticfibrosispatients AT angelikadubbers emergenceofrespiratorystreptococcusagalactiaeisolatesincysticfibrosispatients AT peterkuster emergenceofrespiratorystreptococcusagalactiaeisolatesincysticfibrosispatients AT claudiabrandt emergenceofrespiratorystreptococcusagalactiaeisolatesincysticfibrosispatients AT barbaraspellerberg emergenceofrespiratorystreptococcusagalactiaeisolatesincysticfibrosispatients
_version_	1718413976608440320

Emergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients.

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