A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer

Glucose metabolism is known to be dysregulated in cancer. Here, the authors show that glutamine nitrogen is also affected in cancer and demonstrate that glutaminase 1 and phosphoribosyl pyrophosphate amidotransferase are the key enzymes that control this metabolic switch.

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Autores principales:	Manabu Kodama, Kiyotaka Oshikawa, Hideyuki Shimizu, Susumu Yoshioka, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Chisa Tateishi, Takeshi Tomonaga, Masaki Matsumoto, Keiichi I. Nakayama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3cad8c151ae940c18f28ff460b955637
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spelling	oai:doaj.org-article:3cad8c151ae940c18f28ff460b9556372021-12-02T16:50:02ZA shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer10.1038/s41467-020-15136-92041-1723https://doaj.org/article/3cad8c151ae940c18f28ff460b9556372020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15136-9https://doaj.org/toc/2041-1723Glucose metabolism is known to be dysregulated in cancer. Here, the authors show that glutamine nitrogen is also affected in cancer and demonstrate that glutaminase 1 and phosphoribosyl pyrophosphate amidotransferase are the key enzymes that control this metabolic switch.Manabu KodamaKiyotaka OshikawaHideyuki ShimizuSusumu YoshiokaMasatomo TakahashiYoshihiro IzumiTakeshi BambaChisa TateishiTakeshi TomonagaMasaki MatsumotoKeiichi I. NakayamaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manabu Kodama Kiyotaka Oshikawa Hideyuki Shimizu Susumu Yoshioka Masatomo Takahashi Yoshihiro Izumi Takeshi Bamba Chisa Tateishi Takeshi Tomonaga Masaki Matsumoto Keiichi I. Nakayama A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer
description	Glucose metabolism is known to be dysregulated in cancer. Here, the authors show that glutamine nitrogen is also affected in cancer and demonstrate that glutaminase 1 and phosphoribosyl pyrophosphate amidotransferase are the key enzymes that control this metabolic switch.
format	article
author	Manabu Kodama Kiyotaka Oshikawa Hideyuki Shimizu Susumu Yoshioka Masatomo Takahashi Yoshihiro Izumi Takeshi Bamba Chisa Tateishi Takeshi Tomonaga Masaki Matsumoto Keiichi I. Nakayama
author_facet	Manabu Kodama Kiyotaka Oshikawa Hideyuki Shimizu Susumu Yoshioka Masatomo Takahashi Yoshihiro Izumi Takeshi Bamba Chisa Tateishi Takeshi Tomonaga Masaki Matsumoto Keiichi I. Nakayama
author_sort	Manabu Kodama
title	A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer
title_short	A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer
title_full	A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer
title_fullStr	A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer
title_full_unstemmed	A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer
title_sort	shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3cad8c151ae940c18f28ff460b955637
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A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer

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