A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer
Glucose metabolism is known to be dysregulated in cancer. Here, the authors show that glutamine nitrogen is also affected in cancer and demonstrate that glutaminase 1 and phosphoribosyl pyrophosphate amidotransferase are the key enzymes that control this metabolic switch.
Guardado en:
Autores principales: | Manabu Kodama, Kiyotaka Oshikawa, Hideyuki Shimizu, Susumu Yoshioka, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Chisa Tateishi, Takeshi Tomonaga, Masaki Matsumoto, Keiichi I. Nakayama |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/3cad8c151ae940c18f28ff460b955637 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques
por: Yuta Matsuoka, et al.
Publicado: (2021) -
A universal molecular prognostic score for gastrointestinal tumors
por: Hideyuki Shimizu, et al.
Publicado: (2021) -
Fearful dogs have increased plasma glutamine and γ-glutamyl glutamine
por: Jenni Puurunen, et al.
Publicado: (2018) -
Visualization of glutamine transporter activities in living cells using genetically encoded glutamine sensors.
por: Katrin Gruenwald, et al.
Publicado: (2012) -
Promotion of both proliferation and neuronal differentiation in pluripotent P19 cells with stable overexpression of the glutamine transporter slc38a1.
por: Masato Ogura, et al.
Publicado: (2012)