NQO1 Enzyme and its Role in Cellular Protection; an Insight

NAD(P)H:quinone oxidoreductase 1 (NQO1) is considered as one of the most significant enzyme in cellular defense due to its ability to detoxify reactive quinones and quinone imines to their less toxic hydroquinones forms. NQO1 is a xenobiotic metabolizing cytosolic enzyme that catalyzes the reduction...

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Autores principales:	Ahmed Atia, Azman Abdullah
Formato:	article
Lenguaje:	EN
Publicado:	Emergency Department of Hospital San Pedro (Logroño, Spain) 2020
Materias:	gene expression nqo1 keap1 are Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3caf9d4927b44973b904488336c909ef
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spelling	oai:doaj.org-article:3caf9d4927b44973b904488336c909ef2021-12-02T17:45:29ZNQO1 Enzyme and its Role in Cellular Protection; an Insight10.5281/zenodo.38775282695-5075https://doaj.org/article/3caf9d4927b44973b904488336c909ef2020-06-01T00:00:00Zhttps://doi.org/10.5281/zenodo.3877528https://doaj.org/toc/2695-5075NAD(P)H:quinone oxidoreductase 1 (NQO1) is considered as one of the most significant enzyme in cellular defense due to its ability to detoxify reactive quinones and quinone imines to their less toxic hydroquinones forms. NQO1 is a xenobiotic metabolizing cytosolic enzyme that catalyzes the reduction of two- or four-electron of numerous exogenous and endogenous quinones by utilizing flavin adenine dinucleotide (FAD) as a cofactor. NQO1 enzyme exists as a homodimer enzyme and is biochemically identified by its noticeable ability to utilize either NADH or NADPH as reducing cofactors and by its inhibition by anticoagulant agents such as dicumarol. NQO1 is a distinctly inducible enzyme and known to be controlled by the Nrf2-Keap1 pathway. The importance of the antioxidant activities exhibited by NQO1 enzyme in suppressing the oxidative stress status is provided by demonstration that induction or reduction of NQO1 levels are linked with increased and reduced susceptibilities to oxidative stress, respectively. The gene coding for NQO1 has two well-recognized polymorphisms at nucleotide site 609(C-T) and 465 (C-T) of the human cDNA. C609T causes complete loss of enzymatic activity due to protein instability, whereas the C465T results in reduction of the enzyme activity. In this Review, we deliberate the protecting activates of NQO1 and discussing its possible transcriptional pathways regulating its induction by Nrf2-Keap1/ARE system.Ahmed AtiaAzman AbdullahEmergency Department of Hospital San Pedro (Logroño, Spain)articlegene expressionnqo1keap1areMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 2, Iss 4, Pp 306-313 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	gene expression nqo1 keap1 are Medicine (General) R5-920
spellingShingle	gene expression nqo1 keap1 are Medicine (General) R5-920 Ahmed Atia Azman Abdullah NQO1 Enzyme and its Role in Cellular Protection; an Insight
description	NAD(P)H:quinone oxidoreductase 1 (NQO1) is considered as one of the most significant enzyme in cellular defense due to its ability to detoxify reactive quinones and quinone imines to their less toxic hydroquinones forms. NQO1 is a xenobiotic metabolizing cytosolic enzyme that catalyzes the reduction of two- or four-electron of numerous exogenous and endogenous quinones by utilizing flavin adenine dinucleotide (FAD) as a cofactor. NQO1 enzyme exists as a homodimer enzyme and is biochemically identified by its noticeable ability to utilize either NADH or NADPH as reducing cofactors and by its inhibition by anticoagulant agents such as dicumarol. NQO1 is a distinctly inducible enzyme and known to be controlled by the Nrf2-Keap1 pathway. The importance of the antioxidant activities exhibited by NQO1 enzyme in suppressing the oxidative stress status is provided by demonstration that induction or reduction of NQO1 levels are linked with increased and reduced susceptibilities to oxidative stress, respectively. The gene coding for NQO1 has two well-recognized polymorphisms at nucleotide site 609(C-T) and 465 (C-T) of the human cDNA. C609T causes complete loss of enzymatic activity due to protein instability, whereas the C465T results in reduction of the enzyme activity. In this Review, we deliberate the protecting activates of NQO1 and discussing its possible transcriptional pathways regulating its induction by Nrf2-Keap1/ARE system.
format	article
author	Ahmed Atia Azman Abdullah
author_facet	Ahmed Atia Azman Abdullah
author_sort	Ahmed Atia
title	NQO1 Enzyme and its Role in Cellular Protection; an Insight
title_short	NQO1 Enzyme and its Role in Cellular Protection; an Insight
title_full	NQO1 Enzyme and its Role in Cellular Protection; an Insight
title_fullStr	NQO1 Enzyme and its Role in Cellular Protection; an Insight
title_full_unstemmed	NQO1 Enzyme and its Role in Cellular Protection; an Insight
title_sort	nqo1 enzyme and its role in cellular protection; an insight
publisher	Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate	2020
url	https://doaj.org/article/3caf9d4927b44973b904488336c909ef
work_keys_str_mv	AT ahmedatia nqo1enzymeanditsroleincellularprotectionaninsight AT azmanabdullah nqo1enzymeanditsroleincellularprotectionaninsight
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NQO1 Enzyme and its Role in Cellular Protection; an Insight

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