Islet Transplantation Imaging in vivo

Lei Zheng1 ,* Yinghao Wang1 ,* Bin Yang1,2 ,* Bo Zhang,1,2 Yulian Wu1,2 1Department of Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of China; 2Key Laboratory of Cancer Prevention and Intervention, China National Ministr...

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Autores principales:	Zheng L, Wang Y, Yang B, Zhang B, Wu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	islet transplantation imaging modality non-invasive imaging multimodal imaging contrast agent Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/3cb2803d488f4c08abd7dccf6d2f5f3f
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spelling	oai:doaj.org-article:3cb2803d488f4c08abd7dccf6d2f5f3f2021-12-02T13:01:01ZIslet Transplantation Imaging in vivo1178-7007https://doaj.org/article/3cb2803d488f4c08abd7dccf6d2f5f3f2020-09-01T00:00:00Zhttps://www.dovepress.com/islet-transplantation-imaging-in-vivo-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Lei Zheng1 ,* Yinghao Wang1 ,* Bin Yang1,2 ,* Bo Zhang,1,2 Yulian Wu1,2 1Department of Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of China; 2Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bo Zhang; Yulian WuDepartment of Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of ChinaTel/ Fax +86 571 87783563Email jjs10@zju.edu.cn; yulianwu@zju.edu.cnAbstract: Although islet transplantation plays an effective and powerful role in the treatment of diabetes, a large amount of islet grafts are lost at an early stage due to instant blood-mediated inflammatory reactions, immune rejection, and β-cell toxicity resulting from immunosuppressive agents. Timely intervention based on the viability and function of the transplanted islets at an early stage is crucial. Various islet transplantation imaging techniques are available for monitoring the conditions of post-transplanted islets. Due to the development of various imaging modalities and the continuous study of contrast agents, non-invasive islet transplantation imaging in vivo has made great progress. The tracing and functional evaluation of transplanted islets in vivo have thus become possible. However, most studies on contrast agent and imaging modalities are limited to animal experiments, and long-term toxicity and stability need further evaluation. Accordingly, the clinical application of the current achievements still requires a large amount of effort. In this review, we discuss the contrast agents for MRI, SPECT/PET, BLI/FI, US, MPI, PAI, and multimodal imaging. We further summarize the advantages and limitations of various molecular imaging methods.Keywords: islet transplantation, imaging modality, non-invasive imaging, multimodal imaging, contrast agentZheng LWang YYang BZhang BWu YDove Medical Pressarticleislet transplantationimaging modalitynon-invasive imagingmultimodal imagingcontrast agentSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3301-3311 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	islet transplantation imaging modality non-invasive imaging multimodal imaging contrast agent Specialties of internal medicine RC581-951
spellingShingle	islet transplantation imaging modality non-invasive imaging multimodal imaging contrast agent Specialties of internal medicine RC581-951 Zheng L Wang Y Yang B Zhang B Wu Y Islet Transplantation Imaging in vivo
description	Lei Zheng1 ,* Yinghao Wang1 ,* Bin Yang1,2 ,* Bo Zhang,1,2 Yulian Wu1,2 1Department of Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of China; 2Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bo Zhang; Yulian WuDepartment of Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, People’s Republic of ChinaTel/ Fax +86 571 87783563Email jjs10@zju.edu.cn; yulianwu@zju.edu.cnAbstract: Although islet transplantation plays an effective and powerful role in the treatment of diabetes, a large amount of islet grafts are lost at an early stage due to instant blood-mediated inflammatory reactions, immune rejection, and β-cell toxicity resulting from immunosuppressive agents. Timely intervention based on the viability and function of the transplanted islets at an early stage is crucial. Various islet transplantation imaging techniques are available for monitoring the conditions of post-transplanted islets. Due to the development of various imaging modalities and the continuous study of contrast agents, non-invasive islet transplantation imaging in vivo has made great progress. The tracing and functional evaluation of transplanted islets in vivo have thus become possible. However, most studies on contrast agent and imaging modalities are limited to animal experiments, and long-term toxicity and stability need further evaluation. Accordingly, the clinical application of the current achievements still requires a large amount of effort. In this review, we discuss the contrast agents for MRI, SPECT/PET, BLI/FI, US, MPI, PAI, and multimodal imaging. We further summarize the advantages and limitations of various molecular imaging methods.Keywords: islet transplantation, imaging modality, non-invasive imaging, multimodal imaging, contrast agent
format	article
author	Zheng L Wang Y Yang B Zhang B Wu Y
author_facet	Zheng L Wang Y Yang B Zhang B Wu Y
author_sort	Zheng L
title	Islet Transplantation Imaging in vivo
title_short	Islet Transplantation Imaging in vivo
title_full	Islet Transplantation Imaging in vivo
title_fullStr	Islet Transplantation Imaging in vivo
title_full_unstemmed	Islet Transplantation Imaging in vivo
title_sort	islet transplantation imaging in vivo
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/3cb2803d488f4c08abd7dccf6d2f5f3f
work_keys_str_mv	AT zhengl islettransplantationimaginginvivo AT wangy islettransplantationimaginginvivo AT yangb islettransplantationimaginginvivo AT zhangb islettransplantationimaginginvivo AT wuy islettransplantationimaginginvivo
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Islet Transplantation Imaging in vivo

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