Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis

Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis

Natural killer cells may respond better on second antigen encounters, but how this memory is induced or maintained in vivo is not clear. Here the authors show that memory NK cells expressing interleukin-7 (IL-7) receptor are induced in the lymph nodes but later recruited to liver for long term, IL-7...

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Autores principales: Xianwei Wang, Hui Peng, Jingjing Cong, Xuefu Wang, Zhexiong Lian, Haiming Wei, Rui Sun, Zhigang Tian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/3cb3684889cd478cbcbe3f0f21c7399c
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spelling oai:doaj.org-article:3cb3684889cd478cbcbe3f0f21c7399c2021-12-02T16:56:55ZMemory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis10.1038/s41467-018-07405-52041-1723https://doaj.org/article/3cb3684889cd478cbcbe3f0f21c7399c2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07405-5https://doaj.org/toc/2041-1723Natural killer cells may respond better on second antigen encounters, but how this memory is induced or maintained in vivo is not clear. Here the authors show that memory NK cells expressing interleukin-7 (IL-7) receptor are induced in the lymph nodes but later recruited to liver for long term, IL-7 dependent survival and memory maintenance.Xianwei WangHui PengJingjing CongXuefu WangZhexiong LianHaiming WeiRui SunZhigang TianNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xianwei Wang
Hui Peng
Jingjing Cong
Xuefu Wang
Zhexiong Lian
Haiming Wei
Rui Sun
Zhigang Tian
Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis
description Natural killer cells may respond better on second antigen encounters, but how this memory is induced or maintained in vivo is not clear. Here the authors show that memory NK cells expressing interleukin-7 (IL-7) receptor are induced in the lymph nodes but later recruited to liver for long term, IL-7 dependent survival and memory maintenance.
format article
author Xianwei Wang
Hui Peng
Jingjing Cong
Xuefu Wang
Zhexiong Lian
Haiming Wei
Rui Sun
Zhigang Tian
author_facet Xianwei Wang
Hui Peng
Jingjing Cong
Xuefu Wang
Zhexiong Lian
Haiming Wei
Rui Sun
Zhigang Tian
author_sort Xianwei Wang
title Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis
title_short Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis
title_full Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis
title_fullStr Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis
title_full_unstemmed Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis
title_sort memory formation and long-term maintenance of il-7rα+ ilc1s via a lymph node-liver axis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/3cb3684889cd478cbcbe3f0f21c7399c
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AT huipeng memoryformationandlongtermmaintenanceofil7railc1sviaalymphnodeliveraxis
AT jingjingcong memoryformationandlongtermmaintenanceofil7railc1sviaalymphnodeliveraxis
AT xuefuwang memoryformationandlongtermmaintenanceofil7railc1sviaalymphnodeliveraxis
AT zhexionglian memoryformationandlongtermmaintenanceofil7railc1sviaalymphnodeliveraxis
AT haimingwei memoryformationandlongtermmaintenanceofil7railc1sviaalymphnodeliveraxis
AT ruisun memoryformationandlongtermmaintenanceofil7railc1sviaalymphnodeliveraxis
AT zhigangtian memoryformationandlongtermmaintenanceofil7railc1sviaalymphnodeliveraxis
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