Nanocomposite plasters for the treatment of superficial tumors by chemo-photothermal combination therapy

Wei Qi, Jing Yan, Haifeng Sun, Hua Wang Institute of Medicine and Materials Applied Technologies, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, China Introduction: Novel nanomedical systems are being developed as multiple therapeutic modalities becau...

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Autores principales:	Qi W, Yan J, Sun H, Wang H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	nanocomposite plaster carboxylated reduced graphene oxide doxorubicin Au nanorods superficial tumor Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3cb3d73cd74d44a993ffc5d3abf39168
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spelling	oai:doaj.org-article:3cb3d73cd74d44a993ffc5d3abf391682021-12-02T07:59:58ZNanocomposite plasters for the treatment of superficial tumors by chemo-photothermal combination therapy1178-2013https://doaj.org/article/3cb3d73cd74d44a993ffc5d3abf391682018-10-01T00:00:00Zhttps://www.dovepress.com/nanocomposite-plasters-for-the-treatment-of-superficial-tumors-by-chem-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Wei Qi, Jing Yan, Haifeng Sun, Hua Wang Institute of Medicine and Materials Applied Technologies, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, China Introduction: Novel nanomedical systems are being developed as multiple therapeutic modalities because the combinational therapies for cancer on a single platform can have larger chance to address tumor heterogeneity and drug resistance than any mono-therapeutic modality. Methods: In this study, photothermal therapy (PTT) and chemotherapy (CT) were combined to treat squamous cell carcinoma by using a novel type of noninvasive plaster composed of carboxylated-reduced graphene oxide (rGO–COOH), gold nanorods (Au NRs), and doxorubicin (DOX). Firstly, DOX was loaded onto rGO–COOH to form DOX_rGO–COOH. Then, the obtained DOX_rGO–COOH and Au NRs were co-assembled to obtain nanocomposite multilayer. rGO–COOH and Au NRs were combined together to obtain high light-to-heat conversion efficiency. Using them as photothermal agents for PTT and using DOX in rGO–COOH as an anticancer drug for CT, their synergistic combination therapy could be applicable practically. Results: As a result, DOX_rGO–COOH/Au NRs showed higher photothermal effects than that showed by rGO–COOH or Au NRs alone. It also showed higher therapeutic effects than DOX_rGO–COOH (for CT) or Au nr (for PTT) alone. Moreover, the system can repeatedly produce heat and simultaneously stimulate the release of the encapsulated anticancer drug into the tumor upon being irradiated by near-infrared laser. In vivo experiments demonstrated that the squamous cell carcinoma-bearing mice treated with DOX_rGO–COOH/Au NRs were healthy for more than 60 days without tumor recurrence. Conclusion: The as-developed DOX_rGO–COOH/Au NRs plaster could be an effective, convenient, and noninvasive treatment option for treating superficial tumors. Keywords: nanocomposite plaster, carboxylated-reduced graphene oxide, doxorubicin, Au nanorods, superficial tumorQi WYan JSun HWang HDove Medical Pressarticlenanocomposite plastercarboxylated reduced graphene oxidedoxorubicinAu nanorodssuperficial tumorMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 6235-6247 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanocomposite plaster carboxylated reduced graphene oxide doxorubicin Au nanorods superficial tumor Medicine (General) R5-920
spellingShingle	nanocomposite plaster carboxylated reduced graphene oxide doxorubicin Au nanorods superficial tumor Medicine (General) R5-920 Qi W Yan J Sun H Wang H Nanocomposite plasters for the treatment of superficial tumors by chemo-photothermal combination therapy
description	Wei Qi, Jing Yan, Haifeng Sun, Hua Wang Institute of Medicine and Materials Applied Technologies, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, China Introduction: Novel nanomedical systems are being developed as multiple therapeutic modalities because the combinational therapies for cancer on a single platform can have larger chance to address tumor heterogeneity and drug resistance than any mono-therapeutic modality. Methods: In this study, photothermal therapy (PTT) and chemotherapy (CT) were combined to treat squamous cell carcinoma by using a novel type of noninvasive plaster composed of carboxylated-reduced graphene oxide (rGO–COOH), gold nanorods (Au NRs), and doxorubicin (DOX). Firstly, DOX was loaded onto rGO–COOH to form DOX_rGO–COOH. Then, the obtained DOX_rGO–COOH and Au NRs were co-assembled to obtain nanocomposite multilayer. rGO–COOH and Au NRs were combined together to obtain high light-to-heat conversion efficiency. Using them as photothermal agents for PTT and using DOX in rGO–COOH as an anticancer drug for CT, their synergistic combination therapy could be applicable practically. Results: As a result, DOX_rGO–COOH/Au NRs showed higher photothermal effects than that showed by rGO–COOH or Au NRs alone. It also showed higher therapeutic effects than DOX_rGO–COOH (for CT) or Au nr (for PTT) alone. Moreover, the system can repeatedly produce heat and simultaneously stimulate the release of the encapsulated anticancer drug into the tumor upon being irradiated by near-infrared laser. In vivo experiments demonstrated that the squamous cell carcinoma-bearing mice treated with DOX_rGO–COOH/Au NRs were healthy for more than 60 days without tumor recurrence. Conclusion: The as-developed DOX_rGO–COOH/Au NRs plaster could be an effective, convenient, and noninvasive treatment option for treating superficial tumors. Keywords: nanocomposite plaster, carboxylated-reduced graphene oxide, doxorubicin, Au nanorods, superficial tumor
format	article
author	Qi W Yan J Sun H Wang H
author_facet	Qi W Yan J Sun H Wang H
author_sort	Qi W
title	Nanocomposite plasters for the treatment of superficial tumors by chemo-photothermal combination therapy
title_short	Nanocomposite plasters for the treatment of superficial tumors by chemo-photothermal combination therapy
title_full	Nanocomposite plasters for the treatment of superficial tumors by chemo-photothermal combination therapy
title_fullStr	Nanocomposite plasters for the treatment of superficial tumors by chemo-photothermal combination therapy
title_full_unstemmed	Nanocomposite plasters for the treatment of superficial tumors by chemo-photothermal combination therapy
title_sort	nanocomposite plasters for the treatment of superficial tumors by chemo-photothermal combination therapy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/3cb3d73cd74d44a993ffc5d3abf39168
work_keys_str_mv	AT qiw nanocompositeplastersforthetreatmentofsuperficialtumorsbychemophotothermalcombinationtherapy AT yanj nanocompositeplastersforthetreatmentofsuperficialtumorsbychemophotothermalcombinationtherapy AT sunh nanocompositeplastersforthetreatmentofsuperficialtumorsbychemophotothermalcombinationtherapy AT wangh nanocompositeplastersforthetreatmentofsuperficialtumorsbychemophotothermalcombinationtherapy
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Nanocomposite plasters for the treatment of superficial tumors by chemo-photothermal combination therapy

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