A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

Primary open-angle glaucoma (POAG) leads to progressive vision loss. Here, Choquet et al. perform genome-wide association analysis for POAG in a multi-ethnic cohort, identify a total of nine novel genetic loci and show relevant function of FMNL2 and LMX1B using cell line and mouse experiments.

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Autores principales:	Hélène Choquet, Seyyedhassan Paylakhi, Stephen C. Kneeland, Khanh K. Thai, Thomas J. Hoffmann, Jie Yin, Mark N. Kvale, Yambazi Banda, Nicholas G. Tolman, Pete A. Williams, Catherine Schaefer, Ronald B. Melles, Neil Risch, Simon W. M. John, K. Saidas Nair, Eric Jorgenson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3cb4f5850708427babaf362b4c3b7b49
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spelling	oai:doaj.org-article:3cb4f5850708427babaf362b4c3b7b492021-12-02T16:56:54ZA multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci10.1038/s41467-018-04555-42041-1723https://doaj.org/article/3cb4f5850708427babaf362b4c3b7b492018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04555-4https://doaj.org/toc/2041-1723Primary open-angle glaucoma (POAG) leads to progressive vision loss. Here, Choquet et al. perform genome-wide association analysis for POAG in a multi-ethnic cohort, identify a total of nine novel genetic loci and show relevant function of FMNL2 and LMX1B using cell line and mouse experiments.Hélène ChoquetSeyyedhassan PaylakhiStephen C. KneelandKhanh K. ThaiThomas J. HoffmannJie YinMark N. KvaleYambazi BandaNicholas G. TolmanPete A. WilliamsCatherine SchaeferRonald B. MellesNeil RischSimon W. M. JohnK. Saidas NairEric JorgensonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hélène Choquet Seyyedhassan Paylakhi Stephen C. Kneeland Khanh K. Thai Thomas J. Hoffmann Jie Yin Mark N. Kvale Yambazi Banda Nicholas G. Tolman Pete A. Williams Catherine Schaefer Ronald B. Melles Neil Risch Simon W. M. John K. Saidas Nair Eric Jorgenson A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci
description	Primary open-angle glaucoma (POAG) leads to progressive vision loss. Here, Choquet et al. perform genome-wide association analysis for POAG in a multi-ethnic cohort, identify a total of nine novel genetic loci and show relevant function of FMNL2 and LMX1B using cell line and mouse experiments.
format	article
author	Hélène Choquet Seyyedhassan Paylakhi Stephen C. Kneeland Khanh K. Thai Thomas J. Hoffmann Jie Yin Mark N. Kvale Yambazi Banda Nicholas G. Tolman Pete A. Williams Catherine Schaefer Ronald B. Melles Neil Risch Simon W. M. John K. Saidas Nair Eric Jorgenson
author_facet	Hélène Choquet Seyyedhassan Paylakhi Stephen C. Kneeland Khanh K. Thai Thomas J. Hoffmann Jie Yin Mark N. Kvale Yambazi Banda Nicholas G. Tolman Pete A. Williams Catherine Schaefer Ronald B. Melles Neil Risch Simon W. M. John K. Saidas Nair Eric Jorgenson
author_sort	Hélène Choquet
title	A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci
title_short	A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci
title_full	A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci
title_fullStr	A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci
title_full_unstemmed	A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci
title_sort	multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3cb4f5850708427babaf362b4c3b7b49
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A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

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