Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation

The transcriptional co-activator Prdm16 regulates browning of white adipose tissue (WAT). Here, the authors show that Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to β3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis i...

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Autores principales:	Lei Huang, Dongning Pan, Qingbo Chen, Lihua J. Zhu, Jianhong Ou, Martin Wabitsch, Yong-Xu Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3cb55482fd75495ebcf803c90ad566a9
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spelling	oai:doaj.org-article:3cb55482fd75495ebcf803c90ad566a92021-12-02T14:16:31ZTranscription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation10.1038/s41467-017-00098-22041-1723https://doaj.org/article/3cb55482fd75495ebcf803c90ad566a92017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00098-2https://doaj.org/toc/2041-1723The transcriptional co-activator Prdm16 regulates browning of white adipose tissue (WAT). Here, the authors show that Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to β3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT.Lei HuangDongning PanQingbo ChenLihua J. ZhuJianhong OuMartin WabitschYong-Xu WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Huang Dongning Pan Qingbo Chen Lihua J. Zhu Jianhong Ou Martin Wabitsch Yong-Xu Wang Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation
description	The transcriptional co-activator Prdm16 regulates browning of white adipose tissue (WAT). Here, the authors show that Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to β3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT.
format	article
author	Lei Huang Dongning Pan Qingbo Chen Lihua J. Zhu Jianhong Ou Martin Wabitsch Yong-Xu Wang
author_facet	Lei Huang Dongning Pan Qingbo Chen Lihua J. Zhu Jianhong Ou Martin Wabitsch Yong-Xu Wang
author_sort	Lei Huang
title	Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation
title_short	Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation
title_full	Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation
title_fullStr	Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation
title_full_unstemmed	Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation
title_sort	transcription factor hlx controls a systematic switch from white to brown fat through prdm16-mediated co-activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3cb55482fd75495ebcf803c90ad566a9
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Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation

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