Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation

Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation

The transcriptional co-activator Prdm16 regulates browning of white adipose tissue (WAT). Here, the authors show that Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to β3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis i...

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Autores principales: Lei Huang, Dongning Pan, Qingbo Chen, Lihua J. Zhu, Jianhong Ou, Martin Wabitsch, Yong-Xu Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/3cb55482fd75495ebcf803c90ad566a9
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