Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription

The members of the phosphatidylinositol 3-kinase-related kinase (PIKK) family play vital roles in multiple biological processes, including DNA damage response, metabolism, cell growth, mRNA decay, and transcription. TRRAP, as the only member lacking the enzymatic activity in this family, is an adapt...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bo-Kun Yin, Zhao-Qi Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	TRRAP HAT Sp1 transcription neuro-development neuodegeneration Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/3cb5ade31db242698818cef27005e1ab
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3cb5ade31db242698818cef27005e1ab
record_format	dspace
spelling	oai:doaj.org-article:3cb5ade31db242698818cef27005e1ab2021-11-25T17:56:42ZBeyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription10.3390/ijms2222124451422-00671661-6596https://doaj.org/article/3cb5ade31db242698818cef27005e1ab2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12445https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The members of the phosphatidylinositol 3-kinase-related kinase (PIKK) family play vital roles in multiple biological processes, including DNA damage response, metabolism, cell growth, mRNA decay, and transcription. TRRAP, as the only member lacking the enzymatic activity in this family, is an adaptor protein for several histone acetyltransferase (HAT) complexes and a scaffold protein for multiple transcription factors. TRRAP has been demonstrated to regulate various cellular functions in cell cycle progression, cell stemness maintenance and differentiation, as well as neural homeostasis. TRRAP is known to be an important orchestrator of many molecular machineries in gene transcription by modulating the activity of some key transcription factors, including E2F1, c-Myc, p53, and recently, Sp1. This review summarizes the biological and biochemical studies on the action mode of TRRAP together with the transcription factors, focusing on how TRRAP-HAT mediates the transactivation of Sp1-governing biological processes, including neurodegeneration.Bo-Kun YinZhao-Qi WangMDPI AGarticleTRRAPHATSp1transcriptionneuro-developmentneuodegenerationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12445, p 12445 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TRRAP HAT Sp1 transcription neuro-development neuodegeneration Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	TRRAP HAT Sp1 transcription neuro-development neuodegeneration Biology (General) QH301-705.5 Chemistry QD1-999 Bo-Kun Yin Zhao-Qi Wang Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription
description	The members of the phosphatidylinositol 3-kinase-related kinase (PIKK) family play vital roles in multiple biological processes, including DNA damage response, metabolism, cell growth, mRNA decay, and transcription. TRRAP, as the only member lacking the enzymatic activity in this family, is an adaptor protein for several histone acetyltransferase (HAT) complexes and a scaffold protein for multiple transcription factors. TRRAP has been demonstrated to regulate various cellular functions in cell cycle progression, cell stemness maintenance and differentiation, as well as neural homeostasis. TRRAP is known to be an important orchestrator of many molecular machineries in gene transcription by modulating the activity of some key transcription factors, including E2F1, c-Myc, p53, and recently, Sp1. This review summarizes the biological and biochemical studies on the action mode of TRRAP together with the transcription factors, focusing on how TRRAP-HAT mediates the transactivation of Sp1-governing biological processes, including neurodegeneration.
format	article
author	Bo-Kun Yin Zhao-Qi Wang
author_facet	Bo-Kun Yin Zhao-Qi Wang
author_sort	Bo-Kun Yin
title	Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription
title_short	Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription
title_full	Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription
title_fullStr	Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription
title_full_unstemmed	Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription
title_sort	beyond hat adaptor: trrap liaisons with sp1-mediated transcription
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3cb5ade31db242698818cef27005e1ab
work_keys_str_mv	AT bokunyin beyondhatadaptortrrapliaisonswithsp1mediatedtranscription AT zhaoqiwang beyondhatadaptortrrapliaisonswithsp1mediatedtranscription
_version_	1718411795801047040

Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription

Ejemplares similares