MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

Vascular calcification (VC) increases morbidity and mortality in cardiovascular and metabolic diseases. Here, Kwon et al.show that calcification stimuli induce MDM2- mediated ubiquitination and proteasomal degradation of HDAC1, suggesting a possible therapeutic strategy for treatment of VC patients.

Guardado en:
Detalles Bibliográficos
Autores principales: Duk-Hwa Kwon, Gwang Hyeon Eom, Jeong Hyeon Ko, Sera Shin, Hosouk Joung, Nakwon Choe, Yoon Seok Nam, Hyun-Ki Min, Taewon Kook, Somy Yoon, Wanseok Kang, Yong Sook Kim, Hyung Seok Kim, Hyuck Choi, Jeong-Tae Koh, Nacksung Kim, Youngkeun Ahn, Hyun-Jai Cho, In-Kyu Lee, Dong Ho Park, Kyoungho Suk, Sang Beom Seo, Erin R. Wissing, Susan M. Mendrysa, Kwang-Il Nam, Hyun Kook
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/3cb836d24f374c4490939f3d5e417cb3
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:3cb836d24f374c4490939f3d5e417cb3
record_format dspace
spelling oai:doaj.org-article:3cb836d24f374c4490939f3d5e417cb32021-12-02T16:49:58ZMDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification10.1038/ncomms104922041-1723https://doaj.org/article/3cb836d24f374c4490939f3d5e417cb32016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10492https://doaj.org/toc/2041-1723Vascular calcification (VC) increases morbidity and mortality in cardiovascular and metabolic diseases. Here, Kwon et al.show that calcification stimuli induce MDM2- mediated ubiquitination and proteasomal degradation of HDAC1, suggesting a possible therapeutic strategy for treatment of VC patients.Duk-Hwa KwonGwang Hyeon EomJeong Hyeon KoSera ShinHosouk JoungNakwon ChoeYoon Seok NamHyun-Ki MinTaewon KookSomy YoonWanseok KangYong Sook KimHyung Seok KimHyuck ChoiJeong-Tae KohNacksung KimYoungkeun AhnHyun-Jai ChoIn-Kyu LeeDong Ho ParkKyoungho SukSang Beom SeoErin R. WissingSusan M. MendrysaKwang-Il NamHyun KookNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Duk-Hwa Kwon
Gwang Hyeon Eom
Jeong Hyeon Ko
Sera Shin
Hosouk Joung
Nakwon Choe
Yoon Seok Nam
Hyun-Ki Min
Taewon Kook
Somy Yoon
Wanseok Kang
Yong Sook Kim
Hyung Seok Kim
Hyuck Choi
Jeong-Tae Koh
Nacksung Kim
Youngkeun Ahn
Hyun-Jai Cho
In-Kyu Lee
Dong Ho Park
Kyoungho Suk
Sang Beom Seo
Erin R. Wissing
Susan M. Mendrysa
Kwang-Il Nam
Hyun Kook
MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification
description Vascular calcification (VC) increases morbidity and mortality in cardiovascular and metabolic diseases. Here, Kwon et al.show that calcification stimuli induce MDM2- mediated ubiquitination and proteasomal degradation of HDAC1, suggesting a possible therapeutic strategy for treatment of VC patients.
format article
author Duk-Hwa Kwon
Gwang Hyeon Eom
Jeong Hyeon Ko
Sera Shin
Hosouk Joung
Nakwon Choe
Yoon Seok Nam
Hyun-Ki Min
Taewon Kook
Somy Yoon
Wanseok Kang
Yong Sook Kim
Hyung Seok Kim
Hyuck Choi
Jeong-Tae Koh
Nacksung Kim
Youngkeun Ahn
Hyun-Jai Cho
In-Kyu Lee
Dong Ho Park
Kyoungho Suk
Sang Beom Seo
Erin R. Wissing
Susan M. Mendrysa
Kwang-Il Nam
Hyun Kook
author_facet Duk-Hwa Kwon
Gwang Hyeon Eom
Jeong Hyeon Ko
Sera Shin
Hosouk Joung
Nakwon Choe
Yoon Seok Nam
Hyun-Ki Min
Taewon Kook
Somy Yoon
Wanseok Kang
Yong Sook Kim
Hyung Seok Kim
Hyuck Choi
Jeong-Tae Koh
Nacksung Kim
Youngkeun Ahn
Hyun-Jai Cho
In-Kyu Lee
Dong Ho Park
Kyoungho Suk
Sang Beom Seo
Erin R. Wissing
Susan M. Mendrysa
Kwang-Il Nam
Hyun Kook
author_sort Duk-Hwa Kwon
title MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification
title_short MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification
title_full MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification
title_fullStr MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification
title_full_unstemmed MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification
title_sort mdm2 e3 ligase-mediated ubiquitination and degradation of hdac1 in vascular calcification
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/3cb836d24f374c4490939f3d5e417cb3
work_keys_str_mv AT dukhwakwon mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT gwanghyeoneom mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT jeonghyeonko mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT serashin mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT hosoukjoung mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT nakwonchoe mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT yoonseoknam mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT hyunkimin mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT taewonkook mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT somyyoon mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT wanseokkang mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT yongsookkim mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT hyungseokkim mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT hyuckchoi mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT jeongtaekoh mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT nacksungkim mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT youngkeunahn mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT hyunjaicho mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT inkyulee mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT donghopark mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT kyounghosuk mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT sangbeomseo mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT erinrwissing mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT susanmmendrysa mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT kwangilnam mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
AT hyunkook mdm2e3ligasemediatedubiquitinationanddegradationofhdac1invascularcalcification
_version_ 1718383151904980992

Ejemplares similares