MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

Vascular calcification (VC) increases morbidity and mortality in cardiovascular and metabolic diseases. Here, Kwon et al.show that calcification stimuli induce MDM2- mediated ubiquitination and proteasomal degradation of HDAC1, suggesting a possible therapeutic strategy for treatment of VC patients.

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Auteurs principaux: Duk-Hwa Kwon, Gwang Hyeon Eom, Jeong Hyeon Ko, Sera Shin, Hosouk Joung, Nakwon Choe, Yoon Seok Nam, Hyun-Ki Min, Taewon Kook, Somy Yoon, Wanseok Kang, Yong Sook Kim, Hyung Seok Kim, Hyuck Choi, Jeong-Tae Koh, Nacksung Kim, Youngkeun Ahn, Hyun-Jai Cho, In-Kyu Lee, Dong Ho Park, Kyoungho Suk, Sang Beom Seo, Erin R. Wissing, Susan M. Mendrysa, Kwang-Il Nam, Hyun Kook
Format: article
Langue:EN
Publié: Nature Portfolio 2016
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/3cb836d24f374c4490939f3d5e417cb3
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