Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

The force-induced unfolding and refolding of proteins is speculated to be a key mechanism in the sensing and transduction of mechanical signals in the living cell. Yet, little evidence has been gathered for its existence in vivo. Prominently, stretch-induced unfolding is postulated to be the activat...

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Autores principales: Daniel Porto, Yohei Matsunaga, Barbara Franke, Rhys M Williams, Hiroshi Qadota, Olga Mayans, Guy M Benian, Hang Lu
Formato: article
Lenguaje:EN
Publicado: eLife Sciences Publications Ltd 2021
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Acceso en línea:https://doaj.org/article/3cbb59f548534da7ac17b2502b6e4447
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