Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

A major goal of HIV-1 vaccine development is to produce antigens that can induce broadly neutralizing antibodies. Here the authors examine the underlying causes of HIV-1 envelope metastability and design uncleaved, prefusion-optimized gp140 trimers with potential for use as HIV-1 vaccine antigens.

Guardado en:

Detalles Bibliográficos
Autores principales:	Leopold Kong, Linling He, Natalia de Val, Nemil Vora, Charles D. Morris, Parisa Azadnia, Devin Sok, Bin Zhou, Dennis R. Burton, Andrew B. Ward, Ian A. Wilson, Jiang Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3cbbbe8afb93480b992188ff0d705f74
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3cbbbe8afb93480b992188ff0d705f74
record_format	dspace
spelling	oai:doaj.org-article:3cbbbe8afb93480b992188ff0d705f742021-12-02T15:34:51ZUncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability10.1038/ncomms120402041-1723https://doaj.org/article/3cbbbe8afb93480b992188ff0d705f742016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12040https://doaj.org/toc/2041-1723A major goal of HIV-1 vaccine development is to produce antigens that can induce broadly neutralizing antibodies. Here the authors examine the underlying causes of HIV-1 envelope metastability and design uncleaved, prefusion-optimized gp140 trimers with potential for use as HIV-1 vaccine antigens.Leopold KongLinling HeNatalia de ValNemil VoraCharles D. MorrisParisa AzadniaDevin SokBin ZhouDennis R. BurtonAndrew B. WardIan A. WilsonJiang ZhuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leopold Kong Linling He Natalia de Val Nemil Vora Charles D. Morris Parisa Azadnia Devin Sok Bin Zhou Dennis R. Burton Andrew B. Ward Ian A. Wilson Jiang Zhu Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability
description	A major goal of HIV-1 vaccine development is to produce antigens that can induce broadly neutralizing antibodies. Here the authors examine the underlying causes of HIV-1 envelope metastability and design uncleaved, prefusion-optimized gp140 trimers with potential for use as HIV-1 vaccine antigens.
format	article
author	Leopold Kong Linling He Natalia de Val Nemil Vora Charles D. Morris Parisa Azadnia Devin Sok Bin Zhou Dennis R. Burton Andrew B. Ward Ian A. Wilson Jiang Zhu
author_facet	Leopold Kong Linling He Natalia de Val Nemil Vora Charles D. Morris Parisa Azadnia Devin Sok Bin Zhou Dennis R. Burton Andrew B. Ward Ian A. Wilson Jiang Zhu
author_sort	Leopold Kong
title	Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability
title_short	Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability
title_full	Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability
title_fullStr	Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability
title_full_unstemmed	Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability
title_sort	uncleaved prefusion-optimized gp140 trimers derived from analysis of hiv-1 envelope metastability
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3cbbbe8afb93480b992188ff0d705f74
work_keys_str_mv	AT leopoldkong uncleavedprefusionoptimizedgp140trimersderivedfromanalysisofhiv1envelopemetastability AT linlinghe uncleavedprefusionoptimizedgp140trimersderivedfromanalysisofhiv1envelopemetastability AT nataliadeval uncleavedprefusionoptimizedgp140trimersderivedfromanalysisofhiv1envelopemetastability AT nemilvora uncleavedprefusionoptimizedgp140trimersderivedfromanalysisofhiv1envelopemetastability AT charlesdmorris uncleavedprefusionoptimizedgp140trimersderivedfromanalysisofhiv1envelopemetastability AT parisaazadnia uncleavedprefusionoptimizedgp140trimersderivedfromanalysisofhiv1envelopemetastability AT devinsok uncleavedprefusionoptimizedgp140trimersderivedfromanalysisofhiv1envelopemetastability AT binzhou uncleavedprefusionoptimizedgp140trimersderivedfromanalysisofhiv1envelopemetastability AT dennisrburton uncleavedprefusionoptimizedgp140trimersderivedfromanalysisofhiv1envelopemetastability AT andrewbward uncleavedprefusionoptimizedgp140trimersderivedfromanalysisofhiv1envelopemetastability AT ianawilson uncleavedprefusionoptimizedgp140trimersderivedfromanalysisofhiv1envelopemetastability AT jiangzhu uncleavedprefusionoptimizedgp140trimersderivedfromanalysisofhiv1envelopemetastability
_version_	1718386712546115584

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

Ejemplares similares