Quantitative analysis of retinal and choroidal microvascular changes in patients with diabetes

Abstract The relationship between choroidal and retinal microvascular changes has not yet been well described, and there were limited data on diagnostic ability of optical coherence tomography (OCT)-derived vascular parameters for determining diabetic retinopathy (DR) progression. We quantitatively...

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Autores principales:	Mirinae Kim, Seung Yong Choi, Young-Hoon Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3cbd2e08e64c451fae050a1d43119137
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spelling	oai:doaj.org-article:3cbd2e08e64c451fae050a1d431191372021-12-02T15:08:26ZQuantitative analysis of retinal and choroidal microvascular changes in patients with diabetes10.1038/s41598-018-30699-w2045-2322https://doaj.org/article/3cbd2e08e64c451fae050a1d431191372018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-30699-whttps://doaj.org/toc/2045-2322Abstract The relationship between choroidal and retinal microvascular changes has not yet been well described, and there were limited data on diagnostic ability of optical coherence tomography (OCT)-derived vascular parameters for determining diabetic retinopathy (DR) progression. We quantitatively analyzed OCT-derived vascular parameters at superficial (SCP) and deep retinal capillary plexus (DCP), and choroid. We assessed foveal avascular zone (FAZ), vessel density, vessel length density, and choroidal vascularity index in conjunction with DR stage. In this study, patients with diabetes and healthy controls were retrospectively analyzed. One-hundred seventy-four eyes were divided into six groups as follows: Healthy controls, no DR, mild non-proliferative DR (NPDR), moderate NPDR, severe NPDR, and proliferative DR. There were significant quantitative changes in retinal and choroidal vascular parameters with DR progression. The FAZ area and perimeter correlated positively with worsening DR severity; the FAZ circularity index, retinal vessel density, retinal vessel length density, and choroidal vascularity index correlated negatively with worsening severity. Among these, FAZ circulatory index demonstrated good diagnostic performance for DR. Our results cautiously suggest that functional circulatory disturbances in retinal and choroidal vasculatures occur before DR presents. As DR progresses, DCP retinal microvasculature changes precede SCP changes.Mirinae KimSeung Yong ChoiYoung-Hoon ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mirinae Kim Seung Yong Choi Young-Hoon Park Quantitative analysis of retinal and choroidal microvascular changes in patients with diabetes
description	Abstract The relationship between choroidal and retinal microvascular changes has not yet been well described, and there were limited data on diagnostic ability of optical coherence tomography (OCT)-derived vascular parameters for determining diabetic retinopathy (DR) progression. We quantitatively analyzed OCT-derived vascular parameters at superficial (SCP) and deep retinal capillary plexus (DCP), and choroid. We assessed foveal avascular zone (FAZ), vessel density, vessel length density, and choroidal vascularity index in conjunction with DR stage. In this study, patients with diabetes and healthy controls were retrospectively analyzed. One-hundred seventy-four eyes were divided into six groups as follows: Healthy controls, no DR, mild non-proliferative DR (NPDR), moderate NPDR, severe NPDR, and proliferative DR. There were significant quantitative changes in retinal and choroidal vascular parameters with DR progression. The FAZ area and perimeter correlated positively with worsening DR severity; the FAZ circularity index, retinal vessel density, retinal vessel length density, and choroidal vascularity index correlated negatively with worsening severity. Among these, FAZ circulatory index demonstrated good diagnostic performance for DR. Our results cautiously suggest that functional circulatory disturbances in retinal and choroidal vasculatures occur before DR presents. As DR progresses, DCP retinal microvasculature changes precede SCP changes.
format	article
author	Mirinae Kim Seung Yong Choi Young-Hoon Park
author_facet	Mirinae Kim Seung Yong Choi Young-Hoon Park
author_sort	Mirinae Kim
title	Quantitative analysis of retinal and choroidal microvascular changes in patients with diabetes
title_short	Quantitative analysis of retinal and choroidal microvascular changes in patients with diabetes
title_full	Quantitative analysis of retinal and choroidal microvascular changes in patients with diabetes
title_fullStr	Quantitative analysis of retinal and choroidal microvascular changes in patients with diabetes
title_full_unstemmed	Quantitative analysis of retinal and choroidal microvascular changes in patients with diabetes
title_sort	quantitative analysis of retinal and choroidal microvascular changes in patients with diabetes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3cbd2e08e64c451fae050a1d43119137
work_keys_str_mv	AT mirinaekim quantitativeanalysisofretinalandchoroidalmicrovascularchangesinpatientswithdiabetes AT seungyongchoi quantitativeanalysisofretinalandchoroidalmicrovascularchangesinpatientswithdiabetes AT younghoonpark quantitativeanalysisofretinalandchoroidalmicrovascularchangesinpatientswithdiabetes
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Quantitative analysis of retinal and choroidal microvascular changes in patients with diabetes

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