A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation

A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation

Here, Michael Gollob and colleagues perform a whole exome sequencing study to identify a mutation in the atrial-specific myosin light chain gene MYL4 in a small family with autosomal dominant familial atrial fibrillation. They also test the functionality of this MYL4mutation in zebrafish cardiac fun...

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Autores principales: Nathan Orr, Rima Arnaout, Lorne J. Gula, Danna A. Spears, Peter Leong-Sit, Qiuju Li, Wadea Tarhuni, Sven Reischauer, Vijay S. Chauhan, Matthew Borkovich, Shaheen Uppal, Arnon Adler, Shaun R. Coughlin, Didier Y. R. Stainier, Michael H. Gollob
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/3cbe2796738e4c49b3e6beec3f1f88fe
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Sumario:Here, Michael Gollob and colleagues perform a whole exome sequencing study to identify a mutation in the atrial-specific myosin light chain gene MYL4 in a small family with autosomal dominant familial atrial fibrillation. They also test the functionality of this MYL4mutation in zebrafish cardiac function and recapitulate disease-related phenotypes.

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