A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation

Here, Michael Gollob and colleagues perform a whole exome sequencing study to identify a mutation in the atrial-specific myosin light chain gene MYL4 in a small family with autosomal dominant familial atrial fibrillation. They also test the functionality of this MYL4mutation in zebrafish cardiac fun...

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Autores principales:	Nathan Orr, Rima Arnaout, Lorne J. Gula, Danna A. Spears, Peter Leong-Sit, Qiuju Li, Wadea Tarhuni, Sven Reischauer, Vijay S. Chauhan, Matthew Borkovich, Shaheen Uppal, Arnon Adler, Shaun R. Coughlin, Didier Y. R. Stainier, Michael H. Gollob
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3cbe2796738e4c49b3e6beec3f1f88fe
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spelling	oai:doaj.org-article:3cbe2796738e4c49b3e6beec3f1f88fe2021-12-02T15:34:56ZA mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation10.1038/ncomms113032041-1723https://doaj.org/article/3cbe2796738e4c49b3e6beec3f1f88fe2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11303https://doaj.org/toc/2041-1723Here, Michael Gollob and colleagues perform a whole exome sequencing study to identify a mutation in the atrial-specific myosin light chain gene MYL4 in a small family with autosomal dominant familial atrial fibrillation. They also test the functionality of this MYL4mutation in zebrafish cardiac function and recapitulate disease-related phenotypes.Nathan OrrRima ArnaoutLorne J. GulaDanna A. SpearsPeter Leong-SitQiuju LiWadea TarhuniSven ReischauerVijay S. ChauhanMatthew BorkovichShaheen UppalArnon AdlerShaun R. CoughlinDidier Y. R. StainierMichael H. GollobNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathan Orr Rima Arnaout Lorne J. Gula Danna A. Spears Peter Leong-Sit Qiuju Li Wadea Tarhuni Sven Reischauer Vijay S. Chauhan Matthew Borkovich Shaheen Uppal Arnon Adler Shaun R. Coughlin Didier Y. R. Stainier Michael H. Gollob A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
description	Here, Michael Gollob and colleagues perform a whole exome sequencing study to identify a mutation in the atrial-specific myosin light chain gene MYL4 in a small family with autosomal dominant familial atrial fibrillation. They also test the functionality of this MYL4mutation in zebrafish cardiac function and recapitulate disease-related phenotypes.
format	article
author	Nathan Orr Rima Arnaout Lorne J. Gula Danna A. Spears Peter Leong-Sit Qiuju Li Wadea Tarhuni Sven Reischauer Vijay S. Chauhan Matthew Borkovich Shaheen Uppal Arnon Adler Shaun R. Coughlin Didier Y. R. Stainier Michael H. Gollob
author_facet	Nathan Orr Rima Arnaout Lorne J. Gula Danna A. Spears Peter Leong-Sit Qiuju Li Wadea Tarhuni Sven Reischauer Vijay S. Chauhan Matthew Borkovich Shaheen Uppal Arnon Adler Shaun R. Coughlin Didier Y. R. Stainier Michael H. Gollob
author_sort	Nathan Orr
title	A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
title_short	A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
title_full	A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
title_fullStr	A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
title_full_unstemmed	A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
title_sort	mutation in the atrial-specific myosin light chain gene (myl4) causes familial atrial fibrillation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3cbe2796738e4c49b3e6beec3f1f88fe
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A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation

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