Variations in the oral microbiome are associated with depression in young adults

Abstract A growing body of evidence supports an important role for alterations in the brain-gut-microbiome axis in the aetiology of depression and other psychiatric disorders. The potential role of the oral microbiome in mental health has received little attention, even though it is one of the most...

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Autores principales:	Benjamin Wingfield, Coral Lapsley, Andrew McDowell, Georgios Miliotis, Margaret McLafferty, Siobhan M. O’Neill, Sonya Coleman, T. Martin McGinnity, Anthony J. Bjourson, Elaine K. Murray
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3cbf8cb5ae1e4dd29a9a1642de679cf5
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spelling	oai:doaj.org-article:3cbf8cb5ae1e4dd29a9a1642de679cf52021-12-02T17:56:56ZVariations in the oral microbiome are associated with depression in young adults10.1038/s41598-021-94498-62045-2322https://doaj.org/article/3cbf8cb5ae1e4dd29a9a1642de679cf52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94498-6https://doaj.org/toc/2045-2322Abstract A growing body of evidence supports an important role for alterations in the brain-gut-microbiome axis in the aetiology of depression and other psychiatric disorders. The potential role of the oral microbiome in mental health has received little attention, even though it is one of the most diverse microbiomes in the body and oral dysbiosis has been linked to systemic diseases with an underlying inflammatory aetiology. This study examines the structure and composition of the salivary microbiome for the first time in young adults who met the DSM-IV criteria for depression (n = 40) and matched controls (n = 43) using 16S rRNA gene-based next generation sequencing. Subtle but significant differences in alpha and beta diversity of the salivary microbiome were observed, with clear separation of depressed and healthy control cohorts into distinct clusters. A total of 21 bacterial taxa were found to be differentially abundant in the depressed cohort, including increased Neisseria spp. and Prevotella nigrescens, while 19 taxa had a decreased abundance. In this preliminary study we have shown that the composition of the oral microbiome is associated with depression in young adults. Further studies are now warranted, particuarly investigations into whether such shifts play any role in the underling aetiology of depression.Benjamin WingfieldCoral LapsleyAndrew McDowellGeorgios MiliotisMargaret McLaffertySiobhan M. O’NeillSonya ColemanT. Martin McGinnityAnthony J. BjoursonElaine K. MurrayNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Benjamin Wingfield Coral Lapsley Andrew McDowell Georgios Miliotis Margaret McLafferty Siobhan M. O’Neill Sonya Coleman T. Martin McGinnity Anthony J. Bjourson Elaine K. Murray Variations in the oral microbiome are associated with depression in young adults
description	Abstract A growing body of evidence supports an important role for alterations in the brain-gut-microbiome axis in the aetiology of depression and other psychiatric disorders. The potential role of the oral microbiome in mental health has received little attention, even though it is one of the most diverse microbiomes in the body and oral dysbiosis has been linked to systemic diseases with an underlying inflammatory aetiology. This study examines the structure and composition of the salivary microbiome for the first time in young adults who met the DSM-IV criteria for depression (n = 40) and matched controls (n = 43) using 16S rRNA gene-based next generation sequencing. Subtle but significant differences in alpha and beta diversity of the salivary microbiome were observed, with clear separation of depressed and healthy control cohorts into distinct clusters. A total of 21 bacterial taxa were found to be differentially abundant in the depressed cohort, including increased Neisseria spp. and Prevotella nigrescens, while 19 taxa had a decreased abundance. In this preliminary study we have shown that the composition of the oral microbiome is associated with depression in young adults. Further studies are now warranted, particuarly investigations into whether such shifts play any role in the underling aetiology of depression.
format	article
author	Benjamin Wingfield Coral Lapsley Andrew McDowell Georgios Miliotis Margaret McLafferty Siobhan M. O’Neill Sonya Coleman T. Martin McGinnity Anthony J. Bjourson Elaine K. Murray
author_facet	Benjamin Wingfield Coral Lapsley Andrew McDowell Georgios Miliotis Margaret McLafferty Siobhan M. O’Neill Sonya Coleman T. Martin McGinnity Anthony J. Bjourson Elaine K. Murray
author_sort	Benjamin Wingfield
title	Variations in the oral microbiome are associated with depression in young adults
title_short	Variations in the oral microbiome are associated with depression in young adults
title_full	Variations in the oral microbiome are associated with depression in young adults
title_fullStr	Variations in the oral microbiome are associated with depression in young adults
title_full_unstemmed	Variations in the oral microbiome are associated with depression in young adults
title_sort	variations in the oral microbiome are associated with depression in young adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3cbf8cb5ae1e4dd29a9a1642de679cf5
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Variations in the oral microbiome are associated with depression in young adults

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