Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates

Evidence implicating cancer drivers can be sparse when limited to clonal events. Here, the authors present a retrovirus driven in vivo lymphomagenesis time course including hundreds of thousands of subclonal mutations and demonstrate the utility of these in mapping the selective forces affecting can...

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Autores principales:	Philip Webster, Joanna C. Dawes, Hamlata Dewchand, Katalin Takacs, Barbara Iadarola, Bruce J. Bolt, Juan J. Caceres, Jakub Kaczor, Gopuraja Dharmalingam, Marian Dore, Laurence Game, Thomas Adejumo, James Elliott, Kikkeri Naresh, Mohammad Karimi, Katerina Rekopoulou, Ge Tan, Alberto Paccanaro, Anthony G. Uren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3cbfb68852e24510a503042bbd7eab4d
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spelling	oai:doaj.org-article:3cbfb68852e24510a503042bbd7eab4d2021-12-02T17:32:34ZSubclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates10.1038/s41467-018-05069-92041-1723https://doaj.org/article/3cbfb68852e24510a503042bbd7eab4d2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05069-9https://doaj.org/toc/2041-1723Evidence implicating cancer drivers can be sparse when limited to clonal events. Here, the authors present a retrovirus driven in vivo lymphomagenesis time course including hundreds of thousands of subclonal mutations and demonstrate the utility of these in mapping the selective forces affecting cancer gene loci, including negatively selected mutations.Philip WebsterJoanna C. DawesHamlata DewchandKatalin TakacsBarbara IadarolaBruce J. BoltJuan J. CaceresJakub KaczorGopuraja DharmalingamMarian DoreLaurence GameThomas AdejumoJames ElliottKikkeri NareshMohammad KarimiKaterina RekopoulouGe TanAlberto PaccanaroAnthony G. UrenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Philip Webster Joanna C. Dawes Hamlata Dewchand Katalin Takacs Barbara Iadarola Bruce J. Bolt Juan J. Caceres Jakub Kaczor Gopuraja Dharmalingam Marian Dore Laurence Game Thomas Adejumo James Elliott Kikkeri Naresh Mohammad Karimi Katerina Rekopoulou Ge Tan Alberto Paccanaro Anthony G. Uren Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates
description	Evidence implicating cancer drivers can be sparse when limited to clonal events. Here, the authors present a retrovirus driven in vivo lymphomagenesis time course including hundreds of thousands of subclonal mutations and demonstrate the utility of these in mapping the selective forces affecting cancer gene loci, including negatively selected mutations.
format	article
author	Philip Webster Joanna C. Dawes Hamlata Dewchand Katalin Takacs Barbara Iadarola Bruce J. Bolt Juan J. Caceres Jakub Kaczor Gopuraja Dharmalingam Marian Dore Laurence Game Thomas Adejumo James Elliott Kikkeri Naresh Mohammad Karimi Katerina Rekopoulou Ge Tan Alberto Paccanaro Anthony G. Uren
author_facet	Philip Webster Joanna C. Dawes Hamlata Dewchand Katalin Takacs Barbara Iadarola Bruce J. Bolt Juan J. Caceres Jakub Kaczor Gopuraja Dharmalingam Marian Dore Laurence Game Thomas Adejumo James Elliott Kikkeri Naresh Mohammad Karimi Katerina Rekopoulou Ge Tan Alberto Paccanaro Anthony G. Uren
author_sort	Philip Webster
title	Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates
title_short	Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates
title_full	Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates
title_fullStr	Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates
title_full_unstemmed	Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates
title_sort	subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3cbfb68852e24510a503042bbd7eab4d
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Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates

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