Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease

Abstract Rapid reconfigurations of brain activity support efficient neuronal communication and flexible behaviour. Suboptimal brain dynamics is associated to impaired adaptability, possibly leading to functional deficiencies. We hypothesize that impaired flexibility in brain activity can lead to mot...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pierpaolo Sorrentino, Rosaria Rucco, Fabio Baselice, Rosa De Micco, Alessandro Tessitore, Arjan Hillebrand, Laura Mandolesi, Michael Breakspear, Leonardo L. Gollo, Giuseppe Sorrentino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3cc0ed21c9a048e781e09514a6345333
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3cc0ed21c9a048e781e09514a6345333
record_format	dspace
spelling	oai:doaj.org-article:3cc0ed21c9a048e781e09514a63453332021-12-02T14:03:57ZFlexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease10.1038/s41598-021-83425-42045-2322https://doaj.org/article/3cc0ed21c9a048e781e09514a63453332021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83425-4https://doaj.org/toc/2045-2322Abstract Rapid reconfigurations of brain activity support efficient neuronal communication and flexible behaviour. Suboptimal brain dynamics is associated to impaired adaptability, possibly leading to functional deficiencies. We hypothesize that impaired flexibility in brain activity can lead to motor and cognitive symptoms of Parkinson’s disease (PD). To test this hypothesis, we studied the ‘functional repertoire’—the number of distinct configurations of neural activity—using source-reconstructed magnetoencephalography in PD patients and controls. We found stereotyped brain dynamics and reduced flexibility in PD. The intensity of this reduction was proportional to symptoms severity, which can be explained by beta-band hyper-synchronization. Moreover, the basal ganglia were prominently involved in the abnormal patterns of brain activity. Our findings support the hypotheses that: symptoms in PD relate to impaired brain flexibility, this impairment preferentially involves the basal ganglia, and beta-band hypersynchronization is associated with reduced brain flexibility. These findings highlight the importance of extensive functional repertoires for correct behaviour.Pierpaolo SorrentinoRosaria RuccoFabio BaseliceRosa De MiccoAlessandro TessitoreArjan HillebrandLaura MandolesiMichael BreakspearLeonardo L. GolloGiuseppe SorrentinoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pierpaolo Sorrentino Rosaria Rucco Fabio Baselice Rosa De Micco Alessandro Tessitore Arjan Hillebrand Laura Mandolesi Michael Breakspear Leonardo L. Gollo Giuseppe Sorrentino Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease
description	Abstract Rapid reconfigurations of brain activity support efficient neuronal communication and flexible behaviour. Suboptimal brain dynamics is associated to impaired adaptability, possibly leading to functional deficiencies. We hypothesize that impaired flexibility in brain activity can lead to motor and cognitive symptoms of Parkinson’s disease (PD). To test this hypothesis, we studied the ‘functional repertoire’—the number of distinct configurations of neural activity—using source-reconstructed magnetoencephalography in PD patients and controls. We found stereotyped brain dynamics and reduced flexibility in PD. The intensity of this reduction was proportional to symptoms severity, which can be explained by beta-band hyper-synchronization. Moreover, the basal ganglia were prominently involved in the abnormal patterns of brain activity. Our findings support the hypotheses that: symptoms in PD relate to impaired brain flexibility, this impairment preferentially involves the basal ganglia, and beta-band hypersynchronization is associated with reduced brain flexibility. These findings highlight the importance of extensive functional repertoires for correct behaviour.
format	article
author	Pierpaolo Sorrentino Rosaria Rucco Fabio Baselice Rosa De Micco Alessandro Tessitore Arjan Hillebrand Laura Mandolesi Michael Breakspear Leonardo L. Gollo Giuseppe Sorrentino
author_facet	Pierpaolo Sorrentino Rosaria Rucco Fabio Baselice Rosa De Micco Alessandro Tessitore Arjan Hillebrand Laura Mandolesi Michael Breakspear Leonardo L. Gollo Giuseppe Sorrentino
author_sort	Pierpaolo Sorrentino
title	Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease
title_short	Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease
title_full	Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease
title_fullStr	Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease
title_full_unstemmed	Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease
title_sort	flexible brain dynamics underpins complex behaviours as observed in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3cc0ed21c9a048e781e09514a6345333
work_keys_str_mv	AT pierpaolosorrentino flexiblebraindynamicsunderpinscomplexbehavioursasobservedinparkinsonsdisease AT rosariarucco flexiblebraindynamicsunderpinscomplexbehavioursasobservedinparkinsonsdisease AT fabiobaselice flexiblebraindynamicsunderpinscomplexbehavioursasobservedinparkinsonsdisease AT rosademicco flexiblebraindynamicsunderpinscomplexbehavioursasobservedinparkinsonsdisease AT alessandrotessitore flexiblebraindynamicsunderpinscomplexbehavioursasobservedinparkinsonsdisease AT arjanhillebrand flexiblebraindynamicsunderpinscomplexbehavioursasobservedinparkinsonsdisease AT lauramandolesi flexiblebraindynamicsunderpinscomplexbehavioursasobservedinparkinsonsdisease AT michaelbreakspear flexiblebraindynamicsunderpinscomplexbehavioursasobservedinparkinsonsdisease AT leonardolgollo flexiblebraindynamicsunderpinscomplexbehavioursasobservedinparkinsonsdisease AT giuseppesorrentino flexiblebraindynamicsunderpinscomplexbehavioursasobservedinparkinsonsdisease
_version_	1718392014342455296

Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease

Ejemplares similares