A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism

Abstract Recently, there has been a resurgence of interest in metabolic rewiring of tumors to identify clinically relevant genes. However, most of these studies have had either focused on individual tumors, or are too general, providing a broad outlook on overall changes. In this study, we have firs...

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Autores principales:	Ilir Sheraj, N. Tulin Guray, Sreeparna Banerjee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3cc1184d6a0f49e2be6d1783670ee43c
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spelling	oai:doaj.org-article:3cc1184d6a0f49e2be6d1783670ee43c2021-12-02T16:10:36ZA pan-cancer transcriptomic study showing tumor specific alterations in central metabolism10.1038/s41598-021-93003-32045-2322https://doaj.org/article/3cc1184d6a0f49e2be6d1783670ee43c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93003-3https://doaj.org/toc/2045-2322Abstract Recently, there has been a resurgence of interest in metabolic rewiring of tumors to identify clinically relevant genes. However, most of these studies have had either focused on individual tumors, or are too general, providing a broad outlook on overall changes. In this study, we have first curated an extensive list of genes encoding metabolic enzymes and metabolite transporters relevant to carbohydrate, fatty acid and amino acid oxidation and biosynthesis. Next, we have used publicly available transcriptomic data for 20 different tumor types from The Cancer Genome Atlas Network (TCGA) and focused on differential expression of these genes between tumor and adjacent normal tissue. Our study revealed major transcriptional alterations in genes that are involved in central metabolism. Most tumors exhibit upregulation in carbohydrate and amino acid transporters, increased glycolysis and pentose phosphate pathway, and decreased fatty acid and amino acid oxidation. On the other hand, the expression of genes of the tricarboxylic acid cycle, anaplerotic reactions and electron transport chain differed between tumors. Although most transcriptomic alterations were conserved across many tumor types suggesting the initiation of common regulatory programs, expression changes unique to specific tumors were also identified, which can provide gene expression fingerprints as potential biomarkers or drug targets. Our study also emphasizes the value of transcriptomic data in the deeper understanding of metabolic changes in diseases.Ilir SherajN. Tulin GuraySreeparna BanerjeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ilir Sheraj N. Tulin Guray Sreeparna Banerjee A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism
description	Abstract Recently, there has been a resurgence of interest in metabolic rewiring of tumors to identify clinically relevant genes. However, most of these studies have had either focused on individual tumors, or are too general, providing a broad outlook on overall changes. In this study, we have first curated an extensive list of genes encoding metabolic enzymes and metabolite transporters relevant to carbohydrate, fatty acid and amino acid oxidation and biosynthesis. Next, we have used publicly available transcriptomic data for 20 different tumor types from The Cancer Genome Atlas Network (TCGA) and focused on differential expression of these genes between tumor and adjacent normal tissue. Our study revealed major transcriptional alterations in genes that are involved in central metabolism. Most tumors exhibit upregulation in carbohydrate and amino acid transporters, increased glycolysis and pentose phosphate pathway, and decreased fatty acid and amino acid oxidation. On the other hand, the expression of genes of the tricarboxylic acid cycle, anaplerotic reactions and electron transport chain differed between tumors. Although most transcriptomic alterations were conserved across many tumor types suggesting the initiation of common regulatory programs, expression changes unique to specific tumors were also identified, which can provide gene expression fingerprints as potential biomarkers or drug targets. Our study also emphasizes the value of transcriptomic data in the deeper understanding of metabolic changes in diseases.
format	article
author	Ilir Sheraj N. Tulin Guray Sreeparna Banerjee
author_facet	Ilir Sheraj N. Tulin Guray Sreeparna Banerjee
author_sort	Ilir Sheraj
title	A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism
title_short	A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism
title_full	A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism
title_fullStr	A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism
title_full_unstemmed	A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism
title_sort	pan-cancer transcriptomic study showing tumor specific alterations in central metabolism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3cc1184d6a0f49e2be6d1783670ee43c
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A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism

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