Relationship of subjective and objective sleep measures with physical performance in advanced-stage lung cancer patients

Abstract Advanced lung cancer patients suffer from deteriorated physical function, which negatively impacts physical and psychological health. As little is known about sleep and physical function in this population, this study aimed to examine the association between subjective and objective sleep p...

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Autores principales:	Naomi Takemura, Denise Shuk Ting Cheung, Daniel Yee Tak Fong, Anne Wing Mui Lee, Tai-Chung Lam, James Chung-Man Ho, Tsz Yeung Kam, Jeannie Yin Kwan Chik, Chia-Chin Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3cc3c7bdc6874a62a83114bbbb002932
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spelling	oai:doaj.org-article:3cc3c7bdc6874a62a83114bbbb0029322021-12-02T19:02:37ZRelationship of subjective and objective sleep measures with physical performance in advanced-stage lung cancer patients10.1038/s41598-021-96481-72045-2322https://doaj.org/article/3cc3c7bdc6874a62a83114bbbb0029322021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96481-7https://doaj.org/toc/2045-2322Abstract Advanced lung cancer patients suffer from deteriorated physical function, which negatively impacts physical and psychological health. As little is known about sleep and physical function in this population, this study aimed to examine the association between subjective and objective sleep parameters and physical function among them. 164 advanced lung cancer patients were included. Objective sleep was measured by actigraphy (measured on non-dominant wrist for 72 h), and subjective sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). Performance-based physical function was measured by Timed Up and Go Test (TUGT), 6-Minute Walk Test (6MWT), Sit-to-Stand Test, and One-leg Standing Test. Univariable and multivariable regression analyses were employed to examine the association between sleep and physical function. Total sleep time (TST) was significantly associated with the 6MWT (β = 0.259; 95% CI 0.120, 0.398; P < 0.001), TUGT (β = − 0.012; 95% CI = − 0.017, − 0.008; P < 0.001) and Sit-to-Stand Test (β = 0.027; 95% CI = 0.018, 0.035; P < 0.001) after adjustment for multiple covariates. PSQI global score was only significantly associated with TUGT (β = 0.140; 95% CI = 0.000, 0.280; P = 0.050) after adjustment for multiple covariates. Shorter sleep duration significantly predicted poorer physical performance in advanced lung cancer patients, and more attention is required for those with less than 4.3 h of sleep on average. Trial registration: ClinicalTrials.gov, NCT03482323. Registered 29 March 2018, https://clinicaltrials.gov/ct2/show/NCT03482323 ; ClinicalTrials.gov, NCT04119778. Registered 8 October 2019, https://clinicaltrials.gov/ct2/show/NCT04119778 .Naomi TakemuraDenise Shuk Ting CheungDaniel Yee Tak FongAnne Wing Mui LeeTai-Chung LamJames Chung-Man HoTsz Yeung KamJeannie Yin Kwan ChikChia-Chin LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naomi Takemura Denise Shuk Ting Cheung Daniel Yee Tak Fong Anne Wing Mui Lee Tai-Chung Lam James Chung-Man Ho Tsz Yeung Kam Jeannie Yin Kwan Chik Chia-Chin Lin Relationship of subjective and objective sleep measures with physical performance in advanced-stage lung cancer patients
description	Abstract Advanced lung cancer patients suffer from deteriorated physical function, which negatively impacts physical and psychological health. As little is known about sleep and physical function in this population, this study aimed to examine the association between subjective and objective sleep parameters and physical function among them. 164 advanced lung cancer patients were included. Objective sleep was measured by actigraphy (measured on non-dominant wrist for 72 h), and subjective sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). Performance-based physical function was measured by Timed Up and Go Test (TUGT), 6-Minute Walk Test (6MWT), Sit-to-Stand Test, and One-leg Standing Test. Univariable and multivariable regression analyses were employed to examine the association between sleep and physical function. Total sleep time (TST) was significantly associated with the 6MWT (β = 0.259; 95% CI 0.120, 0.398; P < 0.001), TUGT (β = − 0.012; 95% CI = − 0.017, − 0.008; P < 0.001) and Sit-to-Stand Test (β = 0.027; 95% CI = 0.018, 0.035; P < 0.001) after adjustment for multiple covariates. PSQI global score was only significantly associated with TUGT (β = 0.140; 95% CI = 0.000, 0.280; P = 0.050) after adjustment for multiple covariates. Shorter sleep duration significantly predicted poorer physical performance in advanced lung cancer patients, and more attention is required for those with less than 4.3 h of sleep on average. Trial registration: ClinicalTrials.gov, NCT03482323. Registered 29 March 2018, https://clinicaltrials.gov/ct2/show/NCT03482323 ; ClinicalTrials.gov, NCT04119778. Registered 8 October 2019, https://clinicaltrials.gov/ct2/show/NCT04119778 .
format	article
author	Naomi Takemura Denise Shuk Ting Cheung Daniel Yee Tak Fong Anne Wing Mui Lee Tai-Chung Lam James Chung-Man Ho Tsz Yeung Kam Jeannie Yin Kwan Chik Chia-Chin Lin
author_facet	Naomi Takemura Denise Shuk Ting Cheung Daniel Yee Tak Fong Anne Wing Mui Lee Tai-Chung Lam James Chung-Man Ho Tsz Yeung Kam Jeannie Yin Kwan Chik Chia-Chin Lin
author_sort	Naomi Takemura
title	Relationship of subjective and objective sleep measures with physical performance in advanced-stage lung cancer patients
title_short	Relationship of subjective and objective sleep measures with physical performance in advanced-stage lung cancer patients
title_full	Relationship of subjective and objective sleep measures with physical performance in advanced-stage lung cancer patients
title_fullStr	Relationship of subjective and objective sleep measures with physical performance in advanced-stage lung cancer patients
title_full_unstemmed	Relationship of subjective and objective sleep measures with physical performance in advanced-stage lung cancer patients
title_sort	relationship of subjective and objective sleep measures with physical performance in advanced-stage lung cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3cc3c7bdc6874a62a83114bbbb002932
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Relationship of subjective and objective sleep measures with physical performance in advanced-stage lung cancer patients

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