mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis

ABSTRACT Mark Walker studies the biosynthesis and engineering of bacterial natural products with the long-term goal of identifying new antibiotic compounds. In this mSphere of Influence, he reflects on how “Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the a...

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Autor principal:	Mark C. Walker
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	biosynthesis metabolic engineering natural product Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/3cc8da35460247219436b19bd5ec1fb6
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spelling	oai:doaj.org-article:3cc8da35460247219436b19bd5ec1fb62021-11-15T15:27:54ZmSphere of Influence: Synthetic Biology of Natural Product Biosynthesis10.1128/mSphere.00954-192379-5042https://doaj.org/article/3cc8da35460247219436b19bd5ec1fb62020-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00954-19https://doaj.org/toc/2379-5042ABSTRACT Mark Walker studies the biosynthesis and engineering of bacterial natural products with the long-term goal of identifying new antibiotic compounds. In this mSphere of Influence, he reflects on how “Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A” by K. Yamanaka, K. A. Reynolds, R. D. Kersten, K. S. Ryan, et al. (Proc Natl Acad Sci USA 111:1957–1962, 2014, https://doi.org/10.1073/pnas.1319584111) impacted his thinking on using synthetic biology approaches to study natural product biosynthesis.Mark C. WalkerAmerican Society for Microbiologyarticlebiosynthesismetabolic engineeringnatural productMicrobiologyQR1-502ENmSphere, Vol 5, Iss 1 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	biosynthesis metabolic engineering natural product Microbiology QR1-502
spellingShingle	biosynthesis metabolic engineering natural product Microbiology QR1-502 Mark C. Walker mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis
description	ABSTRACT Mark Walker studies the biosynthesis and engineering of bacterial natural products with the long-term goal of identifying new antibiotic compounds. In this mSphere of Influence, he reflects on how “Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A” by K. Yamanaka, K. A. Reynolds, R. D. Kersten, K. S. Ryan, et al. (Proc Natl Acad Sci USA 111:1957–1962, 2014, https://doi.org/10.1073/pnas.1319584111) impacted his thinking on using synthetic biology approaches to study natural product biosynthesis.
format	article
author	Mark C. Walker
author_facet	Mark C. Walker
author_sort	Mark C. Walker
title	mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis
title_short	mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis
title_full	mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis
title_fullStr	mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis
title_full_unstemmed	mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis
title_sort	msphere of influence: synthetic biology of natural product biosynthesis
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/3cc8da35460247219436b19bd5ec1fb6
work_keys_str_mv	AT markcwalker msphereofinfluencesyntheticbiologyofnaturalproductbiosynthesis
_version_	1718427942042730496

mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis

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