Transcriptional activation during cell reprogramming correlates with the formation of 3D open chromatin hubs

Regulation of chromosome structure plays essential roles in many nuclear processes. Here, the authors present TADdyn, a tool that integrates time-course 3C data, restraint-based modelling, and molecular dynamics to simulate the structural rearrangements of genomic loci and find that during gene acti...

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Autores principales:	Marco Di Stefano, Ralph Stadhouders, Irene Farabella, David Castillo, François Serra, Thomas Graf, Marc A. Marti-Renom
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3ccb8204b8974088a007e811db572305
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spelling	oai:doaj.org-article:3ccb8204b8974088a007e811db5723052021-12-02T15:52:53ZTranscriptional activation during cell reprogramming correlates with the formation of 3D open chromatin hubs10.1038/s41467-020-16396-12041-1723https://doaj.org/article/3ccb8204b8974088a007e811db5723052020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16396-1https://doaj.org/toc/2041-1723Regulation of chromosome structure plays essential roles in many nuclear processes. Here, the authors present TADdyn, a tool that integrates time-course 3C data, restraint-based modelling, and molecular dynamics to simulate the structural rearrangements of genomic loci and find that during gene activation, transcription starting sites contact with open chromatin regions into active physical domains.Marco Di StefanoRalph StadhoudersIrene FarabellaDavid CastilloFrançois SerraThomas GrafMarc A. Marti-RenomNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marco Di Stefano Ralph Stadhouders Irene Farabella David Castillo François Serra Thomas Graf Marc A. Marti-Renom Transcriptional activation during cell reprogramming correlates with the formation of 3D open chromatin hubs
description	Regulation of chromosome structure plays essential roles in many nuclear processes. Here, the authors present TADdyn, a tool that integrates time-course 3C data, restraint-based modelling, and molecular dynamics to simulate the structural rearrangements of genomic loci and find that during gene activation, transcription starting sites contact with open chromatin regions into active physical domains.
format	article
author	Marco Di Stefano Ralph Stadhouders Irene Farabella David Castillo François Serra Thomas Graf Marc A. Marti-Renom
author_facet	Marco Di Stefano Ralph Stadhouders Irene Farabella David Castillo François Serra Thomas Graf Marc A. Marti-Renom
author_sort	Marco Di Stefano
title	Transcriptional activation during cell reprogramming correlates with the formation of 3D open chromatin hubs
title_short	Transcriptional activation during cell reprogramming correlates with the formation of 3D open chromatin hubs
title_full	Transcriptional activation during cell reprogramming correlates with the formation of 3D open chromatin hubs
title_fullStr	Transcriptional activation during cell reprogramming correlates with the formation of 3D open chromatin hubs
title_full_unstemmed	Transcriptional activation during cell reprogramming correlates with the formation of 3D open chromatin hubs
title_sort	transcriptional activation during cell reprogramming correlates with the formation of 3d open chromatin hubs
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3ccb8204b8974088a007e811db572305
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Transcriptional activation during cell reprogramming correlates with the formation of 3D open chromatin hubs

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