Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model

Better tumor models are needed for the neuroendocrine subtype of castration resistant prostate cancer (CRPC-NE). Here, the authors develop patient-derived model from circulating tumor cells of a CRPC-NE patient, and provide insights on the sequential acquisition of driver gene mutations promoting NE...

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Autores principales:	Vincent Faugeroux, Emma Pailler, Marianne Oulhen, Olivier Deas, Laura Brulle-Soumare, Céline Hervieu, Virginie Marty, Kamelia Alexandrova, Kiki C. Andree, Nikolas H. Stoecklein, Dominique Tramalloni, Stefano Cairo, Maud NgoCamus, Claudio Nicotra, Leon W. M. M. Terstappen, Nicolo Manaresi, Valérie Lapierre, Karim Fizazi, Jean-Yves Scoazec, Yohann Loriot, Jean-Gabriel Judde, Françoise Farace
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3ccca0e5b5dc46c78df201565348528a
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spelling	oai:doaj.org-article:3ccca0e5b5dc46c78df201565348528a2021-12-02T14:41:23ZGenetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model10.1038/s41467-020-15426-22041-1723https://doaj.org/article/3ccca0e5b5dc46c78df201565348528a2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15426-2https://doaj.org/toc/2041-1723Better tumor models are needed for the neuroendocrine subtype of castration resistant prostate cancer (CRPC-NE). Here, the authors develop patient-derived model from circulating tumor cells of a CRPC-NE patient, and provide insights on the sequential acquisition of driver gene mutations promoting NE transdifferentiation.Vincent FaugerouxEmma PaillerMarianne OulhenOlivier DeasLaura Brulle-SoumareCéline HervieuVirginie MartyKamelia AlexandrovaKiki C. AndreeNikolas H. StoeckleinDominique TramalloniStefano CairoMaud NgoCamusClaudio NicotraLeon W. M. M. TerstappenNicolo ManaresiValérie LapierreKarim FizaziJean-Yves ScoazecYohann LoriotJean-Gabriel JuddeFrançoise FaraceNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vincent Faugeroux Emma Pailler Marianne Oulhen Olivier Deas Laura Brulle-Soumare Céline Hervieu Virginie Marty Kamelia Alexandrova Kiki C. Andree Nikolas H. Stoecklein Dominique Tramalloni Stefano Cairo Maud NgoCamus Claudio Nicotra Leon W. M. M. Terstappen Nicolo Manaresi Valérie Lapierre Karim Fizazi Jean-Yves Scoazec Yohann Loriot Jean-Gabriel Judde Françoise Farace Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
description	Better tumor models are needed for the neuroendocrine subtype of castration resistant prostate cancer (CRPC-NE). Here, the authors develop patient-derived model from circulating tumor cells of a CRPC-NE patient, and provide insights on the sequential acquisition of driver gene mutations promoting NE transdifferentiation.
format	article
author	Vincent Faugeroux Emma Pailler Marianne Oulhen Olivier Deas Laura Brulle-Soumare Céline Hervieu Virginie Marty Kamelia Alexandrova Kiki C. Andree Nikolas H. Stoecklein Dominique Tramalloni Stefano Cairo Maud NgoCamus Claudio Nicotra Leon W. M. M. Terstappen Nicolo Manaresi Valérie Lapierre Karim Fizazi Jean-Yves Scoazec Yohann Loriot Jean-Gabriel Judde Françoise Farace
author_facet	Vincent Faugeroux Emma Pailler Marianne Oulhen Olivier Deas Laura Brulle-Soumare Céline Hervieu Virginie Marty Kamelia Alexandrova Kiki C. Andree Nikolas H. Stoecklein Dominique Tramalloni Stefano Cairo Maud NgoCamus Claudio Nicotra Leon W. M. M. Terstappen Nicolo Manaresi Valérie Lapierre Karim Fizazi Jean-Yves Scoazec Yohann Loriot Jean-Gabriel Judde Françoise Farace
author_sort	Vincent Faugeroux
title	Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_short	Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_full	Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_fullStr	Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_full_unstemmed	Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_sort	genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived explant model
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3ccca0e5b5dc46c78df201565348528a
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Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model

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