Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model

Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model

Better tumor models are needed for the neuroendocrine subtype of castration resistant prostate cancer (CRPC-NE). Here, the authors develop patient-derived model from circulating tumor cells of a CRPC-NE patient, and provide insights on the sequential acquisition of driver gene mutations promoting NE...

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Auteurs principaux: Vincent Faugeroux, Emma Pailler, Marianne Oulhen, Olivier Deas, Laura Brulle-Soumare, Céline Hervieu, Virginie Marty, Kamelia Alexandrova, Kiki C. Andree, Nikolas H. Stoecklein, Dominique Tramalloni, Stefano Cairo, Maud NgoCamus, Claudio Nicotra, Leon W. M. M. Terstappen, Nicolo Manaresi, Valérie Lapierre, Karim Fizazi, Jean-Yves Scoazec, Yohann Loriot, Jean-Gabriel Judde, Françoise Farace
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Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/3ccca0e5b5dc46c78df201565348528a
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spelling oai:doaj.org-article:3ccca0e5b5dc46c78df201565348528a2021-12-02T14:41:23ZGenetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model10.1038/s41467-020-15426-22041-1723https://doaj.org/article/3ccca0e5b5dc46c78df201565348528a2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15426-2https://doaj.org/toc/2041-1723Better tumor models are needed for the neuroendocrine subtype of castration resistant prostate cancer (CRPC-NE). Here, the authors develop patient-derived model from circulating tumor cells of a CRPC-NE patient, and provide insights on the sequential acquisition of driver gene mutations promoting NE transdifferentiation.Vincent FaugerouxEmma PaillerMarianne OulhenOlivier DeasLaura Brulle-SoumareCéline HervieuVirginie MartyKamelia AlexandrovaKiki C. AndreeNikolas H. StoeckleinDominique TramalloniStefano CairoMaud NgoCamusClaudio NicotraLeon W. M. M. TerstappenNicolo ManaresiValérie LapierreKarim FizaziJean-Yves ScoazecYohann LoriotJean-Gabriel JuddeFrançoise FaraceNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Vincent Faugeroux
Emma Pailler
Marianne Oulhen
Olivier Deas
Laura Brulle-Soumare
Céline Hervieu
Virginie Marty
Kamelia Alexandrova
Kiki C. Andree
Nikolas H. Stoecklein
Dominique Tramalloni
Stefano Cairo
Maud NgoCamus
Claudio Nicotra
Leon W. M. M. Terstappen
Nicolo Manaresi
Valérie Lapierre
Karim Fizazi
Jean-Yves Scoazec
Yohann Loriot
Jean-Gabriel Judde
Françoise Farace
Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
description Better tumor models are needed for the neuroendocrine subtype of castration resistant prostate cancer (CRPC-NE). Here, the authors develop patient-derived model from circulating tumor cells of a CRPC-NE patient, and provide insights on the sequential acquisition of driver gene mutations promoting NE transdifferentiation.
format article
author Vincent Faugeroux
Emma Pailler
Marianne Oulhen
Olivier Deas
Laura Brulle-Soumare
Céline Hervieu
Virginie Marty
Kamelia Alexandrova
Kiki C. Andree
Nikolas H. Stoecklein
Dominique Tramalloni
Stefano Cairo
Maud NgoCamus
Claudio Nicotra
Leon W. M. M. Terstappen
Nicolo Manaresi
Valérie Lapierre
Karim Fizazi
Jean-Yves Scoazec
Yohann Loriot
Jean-Gabriel Judde
Françoise Farace
author_facet Vincent Faugeroux
Emma Pailler
Marianne Oulhen
Olivier Deas
Laura Brulle-Soumare
Céline Hervieu
Virginie Marty
Kamelia Alexandrova
Kiki C. Andree
Nikolas H. Stoecklein
Dominique Tramalloni
Stefano Cairo
Maud NgoCamus
Claudio Nicotra
Leon W. M. M. Terstappen
Nicolo Manaresi
Valérie Lapierre
Karim Fizazi
Jean-Yves Scoazec
Yohann Loriot
Jean-Gabriel Judde
Françoise Farace
author_sort Vincent Faugeroux
title Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_short Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_full Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_fullStr Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_full_unstemmed Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_sort genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived explant model
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/3ccca0e5b5dc46c78df201565348528a
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