Aberrant cortical thickness in neurologically asymptomatic patients with end-stage renal disease

Jianwei Dong,1,* Xiaofen Ma,2,* Wuhong Lin,1 Mengchen Liu,2 Shishun Fu,2 Lihua Yang,1 Guihua Jiang2 1School of Mathematics, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Medical Imaging, Guangdong No. 2 Provincial People’s Hospital, Guangzhou, Peo...

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Autores principales:	Dong J, Ma X, Lin W, Liu M, Fu S, Yang L, Jiang G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Cortical thickness Kidney function Vertex-wise analysis Multivariate analysis Brain morphometry alterations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/3cd1dac60700408b82f67f7ecd8e23ff
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spelling	oai:doaj.org-article:3cd1dac60700408b82f67f7ecd8e23ff2021-12-02T01:38:25ZAberrant cortical thickness in neurologically asymptomatic patients with end-stage renal disease1178-2021https://doaj.org/article/3cd1dac60700408b82f67f7ecd8e23ff2018-08-01T00:00:00Zhttps://www.dovepress.com/aberrant-cortical-thickness-in-neurologically-asymptomatic-patients-wi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jianwei Dong,1,* Xiaofen Ma,2,* Wuhong Lin,1 Mengchen Liu,2 Shishun Fu,2 Lihua Yang,1 Guihua Jiang2 1School of Mathematics, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Medical Imaging, Guangdong No. 2 Provincial People’s Hospital, Guangzhou, People’s Republic of China *These authors contributed equally to this work Purpose: The aim of this study is to investigate the morphology of cortical gray matter in patients with end-stage renal disease (ESRD) and the relationship between cortical thickness and kidney function. Patients and methods: Three-dimensional high-resolution brain structural magnetic resonance imaging data were collected from 35 patients with ESRD (28 men, 18–61 years old) and 40 age- and gender-matched healthy controls (HCs, 32 men, 22–58 years old). Vertex-wise analysis was then performed to compare the brains of the patients with ESRD with those of HCs to identify abnormalities in the brains of the former. Multiple biochemical measures of renal metabolin, vascular risk factors, general cognitive ability, and dialysis duration were correlated with brain morphometry alterations for the patients. Results: Patients with ESRD showed lesser cortical thickness than the HCs. The most significant cluster with decreased cortical thickness was found in the right prefrontal cortex (P<0.05, random-field theory correction). In addition, the four local peak vertices in the prefrontal cluster were lateral prefrontal cortex (Peaks 1 and 2), medial prefrontal cortex (Peak 3), and ventral prefrontal cortex (Peak 4). Significant negative correlations were observed between the cortical thicknesses of all four peak vertices and blood urea nitrogen; a negative correlation, between the cortical thickness in three of four peaks and serum creatinine; and a positive correlation, between cortical thickness in the medial prefrontal cortex (Peak 3) and hemoglobin. Conclusion: These results provided compelling evidence for cortical abnormality of ESRD patients and suggested that kidney function may be the key factor for predicting changes of brain tissue structure. Keywords: cortical thickness, kidney function, vertex-wise analysis, multivariate analysis, brain morphometry alterationsDong JMa XLin WLiu MFu SYang LJiang GDove Medical PressarticleCortical thicknessKidney functionVertex-wise analysisMultivariate analysisBrain morphometry alterationsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1929-1939 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cortical thickness Kidney function Vertex-wise analysis Multivariate analysis Brain morphometry alterations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Cortical thickness Kidney function Vertex-wise analysis Multivariate analysis Brain morphometry alterations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Dong J Ma X Lin W Liu M Fu S Yang L Jiang G Aberrant cortical thickness in neurologically asymptomatic patients with end-stage renal disease
description	Jianwei Dong,1,* Xiaofen Ma,2,* Wuhong Lin,1 Mengchen Liu,2 Shishun Fu,2 Lihua Yang,1 Guihua Jiang2 1School of Mathematics, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Medical Imaging, Guangdong No. 2 Provincial People’s Hospital, Guangzhou, People’s Republic of China *These authors contributed equally to this work Purpose: The aim of this study is to investigate the morphology of cortical gray matter in patients with end-stage renal disease (ESRD) and the relationship between cortical thickness and kidney function. Patients and methods: Three-dimensional high-resolution brain structural magnetic resonance imaging data were collected from 35 patients with ESRD (28 men, 18–61 years old) and 40 age- and gender-matched healthy controls (HCs, 32 men, 22–58 years old). Vertex-wise analysis was then performed to compare the brains of the patients with ESRD with those of HCs to identify abnormalities in the brains of the former. Multiple biochemical measures of renal metabolin, vascular risk factors, general cognitive ability, and dialysis duration were correlated with brain morphometry alterations for the patients. Results: Patients with ESRD showed lesser cortical thickness than the HCs. The most significant cluster with decreased cortical thickness was found in the right prefrontal cortex (P<0.05, random-field theory correction). In addition, the four local peak vertices in the prefrontal cluster were lateral prefrontal cortex (Peaks 1 and 2), medial prefrontal cortex (Peak 3), and ventral prefrontal cortex (Peak 4). Significant negative correlations were observed between the cortical thicknesses of all four peak vertices and blood urea nitrogen; a negative correlation, between the cortical thickness in three of four peaks and serum creatinine; and a positive correlation, between cortical thickness in the medial prefrontal cortex (Peak 3) and hemoglobin. Conclusion: These results provided compelling evidence for cortical abnormality of ESRD patients and suggested that kidney function may be the key factor for predicting changes of brain tissue structure. Keywords: cortical thickness, kidney function, vertex-wise analysis, multivariate analysis, brain morphometry alterations
format	article
author	Dong J Ma X Lin W Liu M Fu S Yang L Jiang G
author_facet	Dong J Ma X Lin W Liu M Fu S Yang L Jiang G
author_sort	Dong J
title	Aberrant cortical thickness in neurologically asymptomatic patients with end-stage renal disease
title_short	Aberrant cortical thickness in neurologically asymptomatic patients with end-stage renal disease
title_full	Aberrant cortical thickness in neurologically asymptomatic patients with end-stage renal disease
title_fullStr	Aberrant cortical thickness in neurologically asymptomatic patients with end-stage renal disease
title_full_unstemmed	Aberrant cortical thickness in neurologically asymptomatic patients with end-stage renal disease
title_sort	aberrant cortical thickness in neurologically asymptomatic patients with end-stage renal disease
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/3cd1dac60700408b82f67f7ecd8e23ff
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Aberrant cortical thickness in neurologically asymptomatic patients with end-stage renal disease

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