Acetylation in Tumor Immune Evasion Regulation

Acetylation is considered as one of the most common types of epigenetic modifications, and aberrant histone acetylation modifications are associated with the pathological process of cancer through the regulation of oncogenes and tumor suppressors. Recent studies have shown that immune system functio...

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Autores principales:	Jun Lu, Xiang He, Lijuan Zhang, Ran Zhang, Wenzheng Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	acetylated modifications tumor immunity acetylases deacetylases cancer immunotherapy Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/3cd4adb8b31a4be6b322c072442aeaff
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spelling	oai:doaj.org-article:3cd4adb8b31a4be6b322c072442aeaff2021-11-22T06:36:35ZAcetylation in Tumor Immune Evasion Regulation1663-981210.3389/fphar.2021.771588https://doaj.org/article/3cd4adb8b31a4be6b322c072442aeaff2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.771588/fullhttps://doaj.org/toc/1663-9812Acetylation is considered as one of the most common types of epigenetic modifications, and aberrant histone acetylation modifications are associated with the pathological process of cancer through the regulation of oncogenes and tumor suppressors. Recent studies have shown that immune system function and tumor immunity can also be affected by acetylation modifications. A comprehensive understanding of the role of acetylation function in cancer is essential, which may help to develop new therapies to improve the prognosis of cancer patients. In this review, we mainly discussed the functions of acetylase and deacetylase in tumor, immune system and tumor immunity, and listed the information of drugs targeting these enzymes in tumor immunotherapy.Jun LuJun LuXiang HeXiang HeLijuan ZhangRan ZhangWenzheng LiFrontiers Media S.A.articleacetylated modificationstumor immunityacetylasesdeacetylasescancer immunotherapyTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acetylated modifications tumor immunity acetylases deacetylases cancer immunotherapy Therapeutics. Pharmacology RM1-950
spellingShingle	acetylated modifications tumor immunity acetylases deacetylases cancer immunotherapy Therapeutics. Pharmacology RM1-950 Jun Lu Jun Lu Xiang He Xiang He Lijuan Zhang Ran Zhang Wenzheng Li Acetylation in Tumor Immune Evasion Regulation
description	Acetylation is considered as one of the most common types of epigenetic modifications, and aberrant histone acetylation modifications are associated with the pathological process of cancer through the regulation of oncogenes and tumor suppressors. Recent studies have shown that immune system function and tumor immunity can also be affected by acetylation modifications. A comprehensive understanding of the role of acetylation function in cancer is essential, which may help to develop new therapies to improve the prognosis of cancer patients. In this review, we mainly discussed the functions of acetylase and deacetylase in tumor, immune system and tumor immunity, and listed the information of drugs targeting these enzymes in tumor immunotherapy.
format	article
author	Jun Lu Jun Lu Xiang He Xiang He Lijuan Zhang Ran Zhang Wenzheng Li
author_facet	Jun Lu Jun Lu Xiang He Xiang He Lijuan Zhang Ran Zhang Wenzheng Li
author_sort	Jun Lu
title	Acetylation in Tumor Immune Evasion Regulation
title_short	Acetylation in Tumor Immune Evasion Regulation
title_full	Acetylation in Tumor Immune Evasion Regulation
title_fullStr	Acetylation in Tumor Immune Evasion Regulation
title_full_unstemmed	Acetylation in Tumor Immune Evasion Regulation
title_sort	acetylation in tumor immune evasion regulation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3cd4adb8b31a4be6b322c072442aeaff
work_keys_str_mv	AT junlu acetylationintumorimmuneevasionregulation AT junlu acetylationintumorimmuneevasionregulation AT xianghe acetylationintumorimmuneevasionregulation AT xianghe acetylationintumorimmuneevasionregulation AT lijuanzhang acetylationintumorimmuneevasionregulation AT ranzhang acetylationintumorimmuneevasionregulation AT wenzhengli acetylationintumorimmuneevasionregulation
_version_	1718418095950790656

Acetylation in Tumor Immune Evasion Regulation

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