PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice

PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice

Identification of cancer genes altered by non-genetic mechanisms in B-cell lymphoma is challenging. Here, the authors report the development of transposon tools to perform genome-wide recessive screens in vivo and validate identified putative tumor suppressor genes using a CRISPR/Cas9 validation pla...

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Autores principales: Julia Weber, Jorge de la Rosa, Carolyn S. Grove, Markus Schick, Lena Rad, Olga Baranov, Alexander Strong, Anja Pfaus, Mathias J. Friedrich, Thomas Engleitner, Robert Lersch, Rupert Öllinger, Michael Grau, Irene Gonzalez Menendez, Manuela Martella, Ursula Kohlhofer, Ruby Banerjee, Maria A. Turchaninova, Anna Scherger, Gary J. Hoffman, Julia Hess, Laura B. Kuhn, Tim Ammon, Johnny Kim, Günter Schneider, Kristian Unger, Ursula Zimber-Strobl, Mathias Heikenwälder, Marc Schmidt-Supprian, Fengtang Yang, Dieter Saur, Pentao Liu, Katja Steiger, Dmitriy M. Chudakov, Georg Lenz, Leticia Quintanilla-Martinez, Ulrich Keller, George S. Vassiliou, Juan Cadiñanos, Allan Bradley, Roland Rad
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/3cd9593b5a3c449085e3011eabf08516
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spelling oai:doaj.org-article:3cd9593b5a3c449085e3011eabf085162021-12-02T15:36:21ZPiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice10.1038/s41467-019-09180-32041-1723https://doaj.org/article/3cd9593b5a3c449085e3011eabf085162019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09180-3https://doaj.org/toc/2041-1723Identification of cancer genes altered by non-genetic mechanisms in B-cell lymphoma is challenging. Here, the authors report the development of transposon tools to perform genome-wide recessive screens in vivo and validate identified putative tumor suppressor genes using a CRISPR/Cas9 validation platform.Julia WeberJorge de la RosaCarolyn S. GroveMarkus SchickLena RadOlga BaranovAlexander StrongAnja PfausMathias J. FriedrichThomas EngleitnerRobert LerschRupert ÖllingerMichael GrauIrene Gonzalez MenendezManuela MartellaUrsula KohlhoferRuby BanerjeeMaria A. TurchaninovaAnna SchergerGary J. HoffmanJulia HessLaura B. KuhnTim AmmonJohnny KimGünter SchneiderKristian UngerUrsula Zimber-StroblMathias HeikenwälderMarc Schmidt-SupprianFengtang YangDieter SaurPentao LiuKatja SteigerDmitriy M. ChudakovGeorg LenzLeticia Quintanilla-MartinezUlrich KellerGeorge S. VassiliouJuan CadiñanosAllan BradleyRoland RadNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Julia Weber
Jorge de la Rosa
Carolyn S. Grove
Markus Schick
Lena Rad
Olga Baranov
Alexander Strong
Anja Pfaus
Mathias J. Friedrich
Thomas Engleitner
Robert Lersch
Rupert Öllinger
Michael Grau
Irene Gonzalez Menendez
Manuela Martella
Ursula Kohlhofer
Ruby Banerjee
Maria A. Turchaninova
Anna Scherger
Gary J. Hoffman
Julia Hess
Laura B. Kuhn
Tim Ammon
Johnny Kim
Günter Schneider
Kristian Unger
Ursula Zimber-Strobl
Mathias Heikenwälder
Marc Schmidt-Supprian
Fengtang Yang
Dieter Saur
Pentao Liu
Katja Steiger
Dmitriy M. Chudakov
Georg Lenz
Leticia Quintanilla-Martinez
Ulrich Keller
George S. Vassiliou
Juan Cadiñanos
Allan Bradley
Roland Rad
PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice
description Identification of cancer genes altered by non-genetic mechanisms in B-cell lymphoma is challenging. Here, the authors report the development of transposon tools to perform genome-wide recessive screens in vivo and validate identified putative tumor suppressor genes using a CRISPR/Cas9 validation platform.
format article
author Julia Weber
Jorge de la Rosa
Carolyn S. Grove
Markus Schick
Lena Rad
Olga Baranov
Alexander Strong
Anja Pfaus
Mathias J. Friedrich
Thomas Engleitner
Robert Lersch
Rupert Öllinger
Michael Grau
Irene Gonzalez Menendez
Manuela Martella
Ursula Kohlhofer
Ruby Banerjee
Maria A. Turchaninova
Anna Scherger
Gary J. Hoffman
Julia Hess
Laura B. Kuhn
Tim Ammon
Johnny Kim
Günter Schneider
Kristian Unger
Ursula Zimber-Strobl
Mathias Heikenwälder
Marc Schmidt-Supprian
Fengtang Yang
Dieter Saur
Pentao Liu
Katja Steiger
Dmitriy M. Chudakov
Georg Lenz
Leticia Quintanilla-Martinez
Ulrich Keller
George S. Vassiliou
Juan Cadiñanos
Allan Bradley
Roland Rad
author_facet Julia Weber
Jorge de la Rosa
Carolyn S. Grove
Markus Schick
Lena Rad
Olga Baranov
Alexander Strong
Anja Pfaus
Mathias J. Friedrich
Thomas Engleitner
Robert Lersch
Rupert Öllinger
Michael Grau
Irene Gonzalez Menendez
Manuela Martella
Ursula Kohlhofer
Ruby Banerjee
Maria A. Turchaninova
Anna Scherger
Gary J. Hoffman
Julia Hess
Laura B. Kuhn
Tim Ammon
Johnny Kim
Günter Schneider
Kristian Unger
Ursula Zimber-Strobl
Mathias Heikenwälder
Marc Schmidt-Supprian
Fengtang Yang
Dieter Saur
Pentao Liu
Katja Steiger
Dmitriy M. Chudakov
Georg Lenz
Leticia Quintanilla-Martinez
Ulrich Keller
George S. Vassiliou
Juan Cadiñanos
Allan Bradley
Roland Rad
author_sort Julia Weber
title PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice
title_short PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice
title_full PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice
title_fullStr PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice
title_full_unstemmed PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice
title_sort piggybac transposon tools for recessive screening identify b-cell lymphoma drivers in mice
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/3cd9593b5a3c449085e3011eabf08516
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